Title:
OXIDIZED COMPOSITE COMPRISING WATER-SOLUBLE CARBOXYPOLYSACCHARIDE AND MAGNETIC IRON OXIDE
Document Type and Number:
WIPO Patent Application WO/1992/022586
Kind Code:
A1
Abstract:
An oxidized composite comprising a water-soluble carboxypolysaccharide and ultrafine magnetic iron oxide particles. It has an extremely reduces toxicity and an excellent stability, exhibits scarcely any or no hypotensive activity even if directly administered into the blood vessel of an animal, is reduced in the activity of platelet agglutination, and is useful in the medical field as, for example, a contrast medium for MRI and a pyrogenic agent for thermotherapy.
Inventors:
HASEGAWA MASAKATSU (JP)
NAGAE HIDEO (JP)
ITO YOSHIO (JP)
MIZUTANI AKIHIRO (JP)
HIROSE KIMIO (JP)
OHGAI MASAHIRO (JP)
YAMASHITA YASUJI (JP)
TOZAWA NAHOKO (JP)
YAMADA KEITO (JP)
KITO KYOJI (JP)
NAGAE HIDEO (JP)
ITO YOSHIO (JP)
MIZUTANI AKIHIRO (JP)
HIROSE KIMIO (JP)
OHGAI MASAHIRO (JP)
YAMASHITA YASUJI (JP)
TOZAWA NAHOKO (JP)
YAMADA KEITO (JP)
KITO KYOJI (JP)
Application Number:
PCT/JP1992/000735
Publication Date:
December 23, 1992
Filing Date:
June 08, 1992
Export Citation:
Assignee:
MEITO SANGYO KK (JP)
International Classes:
C07D239/34; A01N43/54; A01N43/66; A61K33/26; A61K41/00; A61K49/18; C07D239/38; C07D239/47; C07D239/56; C07D239/60; C07D251/30; C07F9/6512; C07F9/6521; C08B31/18; C08B37/02; C08K3/22; C08L3/10; C08L5/00; (IPC1-7): A61K49/00; C08B31/18; C08B37/00; C08B37/02; C08B37/12; C08B37/18
Domestic Patent References:
| WO1988000060A1 | 1988-01-14 |
Foreign References:
| JPS51151320A | 1976-12-25 | |||
| JPH01500196A | 1989-01-26 | |||
| US4452773A | 1984-06-05 | |||
| JPH03134001A | 1991-06-07 | |||
| JPH01235851A | 1989-09-20 | |||
| JPS61233001A | 1986-10-17 | |||
| JPS57109802A | 1982-07-08 | |||
| JPS5742701A | 1982-03-10 | |||
| JPS5913521A | 1984-01-24 | |||
| US4101435A | 1978-07-18 | |||
| US4452773A | 1984-06-05 | |||
| JPH01500196A | 1989-01-26 |
Other References:
CARBOHYD. RES., vol. 11, 1969, pages 77 - 84
ANALYTICAL CHEM., vol. 22, 1950, pages 326
ANALYTICAL CHEM., vol. 25, 1953, pages 1656
POLYMER J., vol. 13, 1981, pages 1037 - 1043
ANALYTICAL CHEM., vol. 22, 1950, pages 326
ANALYTICAL CHEM., vol. 25, 1953, pages 1656
POLYMER J., vol. 13, 1981, pages 1037 - 1043
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