Title:
OXYGEN-GENERATING SCAFFOLD AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2018/092962
Kind Code:
A1
Abstract:
The present invention relates to an oxygen-generating scaffold comprising a polydimethylsiloxane (PDMS)-CaO2 ring structure and a polycaprolactone (PCL) membrane and a method of producing the same. Using the oxygen-generating scaffold according to the present invention makes it possible to overcome the loss of function of islet cells due to apoptosis and necrosis that are caused by insufficient oxygen supply due to encapsulation of islets, and to enhance the survival rate of islets and insulin secretion function with respect to glucose stimulation. In addition, the system is simple, and the risks are relatively low since the external loss of islets can be prevented by injecting the islets through a side thereof. Therefore, the present invention can be widely used in biomedical technology fields such as diabetes treatment using bioartificial islets.
Inventors:
AHN CURIE (KR)
CHO DONG-WOO (KR)
LEE EUN MI (KR)
JUNG JI-IN (KR)
YI HEE-GYEONG (KR)
ZAHID ALAM MD (KR)
CHO DONG-WOO (KR)
LEE EUN MI (KR)
JUNG JI-IN (KR)
YI HEE-GYEONG (KR)
ZAHID ALAM MD (KR)
Application Number:
PCT/KR2016/013466
Publication Date:
May 24, 2018
Filing Date:
November 22, 2016
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
POSTECH ACAD IND FOUND (KR)
POSTECH ACAD IND FOUND (KR)
International Classes:
A61L27/56; A61F2/02; A61L27/18; A61L27/44; A61L27/58
Other References:
LEE, EUN MI: "Effect of an Oxygen-generating Scaffold on the Viability and Insulin Secretion Function of Porcine Neonatal Pancreatic Cell Clusters (NPCCs", A DOCTOR'S THESIS IN MEDICINE, August 2016 (2016-08-01), pages 1 - 93, XP055503037
PEDRAZA, E. ET AL.: "Preventing Hypoxia-induced Cell Death in Beta Cells and Islets via Hydrolytically Activated, Oxygen-generating Biomaterials", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 109, 2012, pages 4245 - 4250, XP055503057
NYITRAY, C. E. ET AL.: "Polycaprolactone Thin-film Micro- and Nanoporous Cell -encapsulation Devices", ACS NANO, vol. 9, 2015, pages 5675 - 5682, XP055318977
LUDWIG, B ET AL.: "Improvement of Islet Function in a Bioartificial Pancreas by Enhanced Oxygen Supply and Growth Hormone Releasing Hormone Agonist", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 109, 2012, pages 5022 - 5027, XP055269688
OH, S. H. ET AL.: "Oxygen Generating Scaffolds for Enhancing Engineered Tissue Survival", BIOMATERIALS, vol. 30, 2009, pages 757 - 762, XP025801467
WANG, J. ET AL.: "Oxygen-generating Nanofiber Cell Scaffolds with Antimicrobial Properties", ACS APPLIED MATERIALS & INTERFACES, vol. 3, 2010, pages 67 - 73, XP055503062
PEDRAZA, E. ET AL.: "Preventing Hypoxia-induced Cell Death in Beta Cells and Islets via Hydrolytically Activated, Oxygen-generating Biomaterials", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 109, 2012, pages 4245 - 4250, XP055503057
NYITRAY, C. E. ET AL.: "Polycaprolactone Thin-film Micro- and Nanoporous Cell -encapsulation Devices", ACS NANO, vol. 9, 2015, pages 5675 - 5682, XP055318977
LUDWIG, B ET AL.: "Improvement of Islet Function in a Bioartificial Pancreas by Enhanced Oxygen Supply and Growth Hormone Releasing Hormone Agonist", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 109, 2012, pages 5022 - 5027, XP055269688
OH, S. H. ET AL.: "Oxygen Generating Scaffolds for Enhancing Engineered Tissue Survival", BIOMATERIALS, vol. 30, 2009, pages 757 - 762, XP025801467
WANG, J. ET AL.: "Oxygen-generating Nanofiber Cell Scaffolds with Antimicrobial Properties", ACS APPLIED MATERIALS & INTERFACES, vol. 3, 2010, pages 67 - 73, XP055503062
Attorney, Agent or Firm:
CHO, Young Hyun (KR)
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