Title:
PRE-mRNA SPLICING SCREENING ASSAY
Document Type and Number:
WIPO Patent Application WO2002095417
Kind Code:
A3
Abstract:
The present invention relates to a method for screening agents which modulate the binding of CDC5L to PLRG1, or specified fragments thereof, and agents identified using such an assay. The present invention also provides small peptides capable of inhibiting pre-mRNA splicing. Such agents are candidates for use in the treatment of , for example, cancer, or fungal infections.
Inventors:
LAMOND ANGUS IAIN (GB)
MUNYA PAUL AJUH (GB)
MUNYA PAUL AJUH (GB)
Application Number:
PCT/GB2002/002393
Publication Date:
April 01, 2004
Filing Date:
May 20, 2002
Export Citation:
Assignee:
UNIV DUNDEE (GB)
LAMOND ANGUS IAIN (GB)
MUNYA PAUL AJUH (GB)
LAMOND ANGUS IAIN (GB)
MUNYA PAUL AJUH (GB)
International Classes:
A61P31/10; A61P35/00; G01N33/68; (IPC1-7): G01N33/68; A61P35/00; A61P31/10; C07K7/00; C07K14/00; A61K38/00
Other References:
AJUH PAUL ET AL: "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 19, no. 23, 1 December 2000 (2000-12-01), pages 6569 - 6581, XP001154227, ISSN: 0261-4189
BERNSTEIN HAROLD S ET AL: "Pombe Cdc5-related protein: A putative human transcription factor implicated in mitogen-activated signaling.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 9, 1997, pages 5833 - 5837, XP001153968, ISSN: 0021-9258
ISHIKAWA K-I ET AL: "PREDICTION OF THE CODING SEQUENCES OF UNIDENTIFIED HUMAN GENES. VIII. 78 NEW CDNA CLONES FROM BRAIN WHICH CODE FOR LARGE PROTEINS IN VITRO", DNA RESEARCH, UNIVERSAL ACADEMY PRESS, JP, vol. 4, 31 October 1997 (1997-10-31), pages 307 - 313, XP002066665, ISSN: 1340-2838
AJUH PAUL ET AL: "A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 45, 9 November 2001 (2001-11-09), November 9, 2001, pages 42370 - 42381, XP001154228, ISSN: 0021-9258
DATABASE SWALL [online] 1 May 2000 (2000-05-01), XP002263218, retrieved from EBI Database accession no. Q9W0R0
DATABASE SWALL [online] 1 December 2001 (2001-12-01), XP002263219, retrieved from EBI Database accession no. Q96WP6
DATABASE SWALL [online] 1 March 2001 (2001-03-01), XP002263220, retrieved from EBI Database accession no. Q9GNU7
BERNSTEIN HAROLD S ET AL: "Pombe Cdc5-related protein: A putative human transcription factor implicated in mitogen-activated signaling.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 9, 1997, pages 5833 - 5837, XP001153968, ISSN: 0021-9258
ISHIKAWA K-I ET AL: "PREDICTION OF THE CODING SEQUENCES OF UNIDENTIFIED HUMAN GENES. VIII. 78 NEW CDNA CLONES FROM BRAIN WHICH CODE FOR LARGE PROTEINS IN VITRO", DNA RESEARCH, UNIVERSAL ACADEMY PRESS, JP, vol. 4, 31 October 1997 (1997-10-31), pages 307 - 313, XP002066665, ISSN: 1340-2838
AJUH PAUL ET AL: "A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 45, 9 November 2001 (2001-11-09), November 9, 2001, pages 42370 - 42381, XP001154228, ISSN: 0021-9258
DATABASE SWALL [online] 1 May 2000 (2000-05-01), XP002263218, retrieved from EBI Database accession no. Q9W0R0
DATABASE SWALL [online] 1 December 2001 (2001-12-01), XP002263219, retrieved from EBI Database accession no. Q96WP6
DATABASE SWALL [online] 1 March 2001 (2001-03-01), XP002263220, retrieved from EBI Database accession no. Q9GNU7
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