Title:
PROTEIN SPECIFIC TO HUMAN Th2, GENE (B19) ENCODING THE SAME, AND TRANSFORMANT, RECOMBINANT VECTOR AND MONOCLONAL ANTIBODY RELATING THERETO
Document Type and Number:
WIPO Patent Application WO/1997/046677
Kind Code:
A1
Abstract:
A gene (B19) specific exclusively to human Th2 which has been prepared and identified by the subtraction method; a recombinant vector having this gene integrated thereinto; a transformant transformed by this vector; a protein specific to human Th2 encoded by the above-mentioned gene originating in the transformant; a monoclonal antibody against this human Th2-specific protein, and the use of the above-mentioned gene, protein, antibody, etc., in the identification or correction of the polarization in the distribution of Th1 and Th2, which are the subsets of helper T cells, to thereby establish means for identifying the progression or type of immunological diseases based on the information thus obtained.
Inventors:
OGAWA KAZUYUKI (JP)
TANAKA KAZUYA (JP)
NAGATA KINYA (JP)
TAKANO SYOICHI (JP)
TANAKA KAZUYA (JP)
NAGATA KINYA (JP)
TAKANO SYOICHI (JP)
Application Number:
PCT/JP1997/001906
Publication Date:
December 11, 1997
Filing Date:
June 05, 1997
Export Citation:
Assignee:
BML INC (JP)
OGAWA KAZUYUKI (JP)
TANAKA KAZUYA (JP)
NAGATA KINYA (JP)
TAKANO SYOICHI (JP)
OGAWA KAZUYUKI (JP)
TANAKA KAZUYA (JP)
NAGATA KINYA (JP)
TAKANO SYOICHI (JP)
International Classes:
C07K14/47; C07K14/705; C07K16/28; C12N15/12; C12P21/08; A61K38/00; (IPC1-7): C12N15/12; C07K14/435; C12P21/08
Domestic Patent References:
| WO1996027603A1 | 1996-09-12 |
Other References:
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), HILLIER L, ET AL: "ZC04D03.S1 SOARES PARATHYROID TUMOR NBHPA HOMO SAPIENS CDNA CLONE IMAGE:321317 3', MRNA SEQUENCE", XP002908974, Database accession no. W32218
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), HILLIER L, ET AL: "ZA82G07.S1 SOARES FETAL LUNG NBHL19W HOMO SAPIENS CDNA CLONE IMAGE:299100 3' , MNRA SEQUENCE", XP002908975, Database accession no. N75434
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), HILLIER L, ET AL: "YR52B06.R1 SOARES FETAL LIVER SPLEEN 1NFLS HOMO SAPIENS CDNA CLONE IMAGE:208883 5', MRNA SEQUENCE", XP002908976, Database accession no. H63797
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), HILLIER L, ET AL: "YR52B06.S1 SOARES FETAL LIVER SPLEEN 1NFLS HOMO SAPIENS CDNA CLONE IMAGE:208883 3', MRNA SEQUENCE", XP002908977, Database accession no. H63756
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), HILLIER L, ET AL: "YG63E12.R1 SOARES INFANT BRAIN 1NIB HOMO SAPIENS CDNA CLONE IMAGE:37277 5', MRNA SEQUENCE", XP002908978, Database accession no. R26634
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), HILLIER L, ET AL: "YG63E12.S1 SOARES INFANT BRAIN 1NIB HOMO SAPIENS CDNA CLONE IMAGE:37277 3', MRNA SEQUENCE", XP002908979, Database accession no. R49664
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), HILLIER L, ET AL: "YF49H12.R1 SOARES INFANT BRAIN 1NIB HOMO SAPIENS CDNA CLONE IMAGE:25625 5', MRNA SEQUENCE", XP002908980, Database accession no. R11893
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), HILLIER L, ET AL: "ZH70G11.S1 SOARES FETAL LIVER SPLEEN 1NFLS S1 HOMO SAPIENS CDNA CLONE IMAGE:417476 3', MRNA SEQUENCE", XP002908981, Database accession no. W88584
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), BERRY R, ET AL: "IB1021 INFANT BRAIN, BENTO SOARES HOMO SAPIENS CDNA 3'END, MRNA SEQUENCE", XP002908982, Database accession no. T15367
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), HILLIER L, ET AL: "ZR66F03.SL SOARES NHHMPU-S1 HOMO SAPIENS CDNA CLONE IMAGE:668381 3', MRNA SEQUENCE", XP002908983, Database accession no. AA243021
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), HILLIER L, ET AL: "ZR36G11.S1 SOARES NHHMPU S1 HOMO SAPIENS CDNA CLONE IMAGE:665540 3', MRNA SEQUENCE", XP002908984, Database accession no. AA195419
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), HILLIER L, ET AL: "ZM79D05.S1 STRATAGENE NEUROEPITHELIUM (937231) HOMO SAPIENS DNA CLONE IMAGE:531849 3', ,MRNA SEQUENCE", XP002908985, Database accession no. AA126280
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), HILLIER L, ET AL: "ZI03E02.R1 SOARES FETAL LIVER SPLEEN 1NFLS S1 HOMO SAPIENS CDNA CLONE IMAGE:429722 5', MRNA SEQUENCE", XP002908986, Database accession no. AA011713
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), HILLIER L, ET AL: "ZI03E02.SL SOARES FETAL LIVER SPLEEN 1NFLS S1 HOMO SAPIENS CDNA CLONE IMAGE:429722 3', MRNA SEQUENCE", XP002908987, Database accession no. AA011676
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), HILLIER L, ET AL: "ZC19F01.SL SOARES PARATHYROID TUMOR NBHPA HOMO SAPIENS CDNA CLONE IMAGE:22777 3ยข, MRNA SEQUENCE", XP002908988, Database accession no. W15244
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), HILLIER L, ET AL: "ZA82G07.S1 SOARES FETAL LUNG NBHL19W HOMO SAPIENS CDNA CLONE IMAGE:299100 3' , MNRA SEQUENCE", XP002908975, Database accession no. N75434
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), HILLIER L, ET AL: "YR52B06.R1 SOARES FETAL LIVER SPLEEN 1NFLS HOMO SAPIENS CDNA CLONE IMAGE:208883 5', MRNA SEQUENCE", XP002908976, Database accession no. H63797
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), HILLIER L, ET AL: "YR52B06.S1 SOARES FETAL LIVER SPLEEN 1NFLS HOMO SAPIENS CDNA CLONE IMAGE:208883 3', MRNA SEQUENCE", XP002908977, Database accession no. H63756
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), HILLIER L, ET AL: "YG63E12.R1 SOARES INFANT BRAIN 1NIB HOMO SAPIENS CDNA CLONE IMAGE:37277 5', MRNA SEQUENCE", XP002908978, Database accession no. R26634
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), HILLIER L, ET AL: "YG63E12.S1 SOARES INFANT BRAIN 1NIB HOMO SAPIENS CDNA CLONE IMAGE:37277 3', MRNA SEQUENCE", XP002908979, Database accession no. R49664
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), HILLIER L, ET AL: "YF49H12.R1 SOARES INFANT BRAIN 1NIB HOMO SAPIENS CDNA CLONE IMAGE:25625 5', MRNA SEQUENCE", XP002908980, Database accession no. R11893
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), HILLIER L, ET AL: "ZH70G11.S1 SOARES FETAL LIVER SPLEEN 1NFLS S1 HOMO SAPIENS CDNA CLONE IMAGE:417476 3', MRNA SEQUENCE", XP002908981, Database accession no. W88584
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), BERRY R, ET AL: "IB1021 INFANT BRAIN, BENTO SOARES HOMO SAPIENS CDNA 3'END, MRNA SEQUENCE", XP002908982, Database accession no. T15367
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), HILLIER L, ET AL: "ZR66F03.SL SOARES NHHMPU-S1 HOMO SAPIENS CDNA CLONE IMAGE:668381 3', MRNA SEQUENCE", XP002908983, Database accession no. AA243021
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), HILLIER L, ET AL: "ZR36G11.S1 SOARES NHHMPU S1 HOMO SAPIENS CDNA CLONE IMAGE:665540 3', MRNA SEQUENCE", XP002908984, Database accession no. AA195419
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), HILLIER L, ET AL: "ZM79D05.S1 STRATAGENE NEUROEPITHELIUM (937231) HOMO SAPIENS DNA CLONE IMAGE:531849 3', ,MRNA SEQUENCE", XP002908985, Database accession no. AA126280
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), HILLIER L, ET AL: "ZI03E02.R1 SOARES FETAL LIVER SPLEEN 1NFLS S1 HOMO SAPIENS CDNA CLONE IMAGE:429722 5', MRNA SEQUENCE", XP002908986, Database accession no. AA011713
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), HILLIER L, ET AL: "ZI03E02.SL SOARES FETAL LIVER SPLEEN 1NFLS S1 HOMO SAPIENS CDNA CLONE IMAGE:429722 3', MRNA SEQUENCE", XP002908987, Database accession no. AA011676
DATABASE MPSRCH GENBANK 1 January 1900 (1900-01-01), HILLIER L, ET AL: "ZC19F01.SL SOARES PARATHYROID TUMOR NBHPA HOMO SAPIENS CDNA CLONE IMAGE:22777 3ยข, MRNA SEQUENCE", XP002908988, Database accession no. W15244
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