Title:
PTANs: TESTIS SPECIFIC PROTEINS EXPRESSED IN PROSTATE CANCER
Document Type and Number:
WIPO Patent Application WO2000020589
Kind Code:
A9
Abstract:
Novel testis-specific genes and encoded proteins (PTANs) are described. PTANs are over-expressed in prostate cancer. The nucleotide and amino acid sequences of three distinct PTAN isoforms, designated PTAN-1, PTAN-2 and PTAN-3 are provided. The PTANs show no homology to any known gene. The testis-specific expression profile of PTAN in normal adult tissues, combined with the over-expression observed in prostate tumor xenografts, suggests that PTAN may be aberrantly over-expressed in at least some prostate cancers, and thus may be a useful diagnostic and/or therapeutic target for prostate cancers.
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Inventors:
AFAR DANIEL E (US)
HUBERT RENE S (US)
RAITANO ARTHUR B (US)
MITCHELL STEPHEN CHAPPELL (US)
HUBERT RENE S (US)
RAITANO ARTHUR B (US)
MITCHELL STEPHEN CHAPPELL (US)
Application Number:
PCT/US1999/022985
Publication Date:
December 07, 2000
Filing Date:
September 30, 1999
Export Citation:
Assignee:
UROGENESYS INC (US)
AFAR DANIEL E (US)
HUBERT RENE S (US)
RAITANO ARTHUR B (US)
MITCHELL STEPHEN CHAPPELL (US)
AFAR DANIEL E (US)
HUBERT RENE S (US)
RAITANO ARTHUR B (US)
MITCHELL STEPHEN CHAPPELL (US)
International Classes:
C07K14/47; C12N15/12; A61K38/00; A61K39/00; (IPC1-7): C12N15/12; C12N5/10; C07K14/47; C07K16/18; G01N33/574; C12Q1/68; A61K38/17; A61K39/395; A01K67/027; A61P35/00
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