Title:
PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVE AND NAD(P)H OXIDASE INHIBITOR CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO/2003/091256
Kind Code:
A1
Abstract:
A compound represented by the formula (Ia) (wherein R1a, R2a, and R3 to R5 are the same as defined in the description), a prodrug thereof, a pharmaceutically acceptable salt thereof, or a solvate thereof. They are useful in the prevention of or treatments for diseases relating to NAD(P)H.
Inventors:
SENO KAORU (JP)
NISHI KOICHI (JP)
MATSUO YOSHIYUKI (JP)
FUJISHITA TOSHIO (JP)
NISHI KOICHI (JP)
MATSUO YOSHIYUKI (JP)
FUJISHITA TOSHIO (JP)
Application Number:
PCT/JP2003/005024
Publication Date:
November 06, 2003
Filing Date:
April 18, 2003
Export Citation:
Assignee:
SHIONOGI & CO (JP)
SENO KAORU (JP)
NISHI KOICHI (JP)
MATSUO YOSHIYUKI (JP)
FUJISHITA TOSHIO (JP)
SENO KAORU (JP)
NISHI KOICHI (JP)
MATSUO YOSHIYUKI (JP)
FUJISHITA TOSHIO (JP)
International Classes:
A61K31/519; A61K31/5377; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P27/02; A61P29/00; A61P43/00; C07D487/04; C07D519/00; (IPC1-7): C07D487/04; A61K31/519; A61K31/5377; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P27/02; A61P29/00; A61P43/00
Domestic Patent References:
| WO1999018076A1 | 1999-04-15 | |||
| WO2001090101A1 | 2001-11-29 | |||
| WO2002028820A1 | 2002-04-11 | |||
| WO2002024613A2 | 2002-03-28 | |||
| WO1999010313A1 | 1999-03-04 | |||
| WO1999059526A2 | 1999-11-25 |
Foreign References:
| GB1568962A | 1980-06-11 | |||
| GB1579362A | 1980-11-19 | |||
| US20020132826A1 | 2002-09-19 | |||
| US20010046989A1 | 2001-11-29 | |||
| US20010025047A1 | 2001-09-27 | |||
| US6229011B1 | 2001-05-08 | |||
| US5888941A | 1999-03-30 | |||
| US5478838A | 1995-12-26 | |||
| US4918074A | 1990-04-17 | |||
| US4992442A | 1991-02-12 | |||
| JPH07267960A | 1995-10-17 | |||
| JP2001302666A | 2001-10-31 |
Other References:
ELWORTHY T.R.: "N-arylpiperazinyl-n'-propylamino derivatives of heteroaryl amides as functional uroselective 1-adenoceptor antagonists", JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, no. 17, 1997, pages 2674 - 2687, XP002191535
TAKAMIZAWA A.: "Studies on pyrimidine derivatives and related compounds. LIX. Syntheses of 2,3-dihydro-1H-pyrarolo(5,1-b)purin-2-ones", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 16, no. 11, 1968, pages 2195 - 2199, XP002970048
BARTROLI J.: "New azole antifungals. 2. Synthesis and antifungal activity of heterocyclecarboxamide derivatives of 3-amino-2-aryl-1-azolyl-2-butanol", JOURNAL OF MEDICINAL CHEMISTRY, vol. 41, no. 11, 1998, pages 1855 - 1868, XP001121008
NOVINSON T.: "Synthesis and antifungal properties of certain 7-alkylaminopyrazolo(1,5-a)pyrimidines", JOURNAL OF MEDICINAL CHEMISTRY, vol. 20, no. 2, 1977, pages 296 - 299, XP002970049
MUSTAZZA C.: "Synthesis of pyrazolo(1,5-a)-, 1,2,4-triazolo(1,5-a)- and imidazo(1,2-a)pyrimidines related to zaleplon, a new drug for the treatment of insomnia", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 38, no. 5, 2001, pages 1119 - 1129, XP002963286
CHEMICAL ABSTRACTS, vol. 54, no. 1-3, 1960, Columbus, Ohio, US; abstract no. 54:2332I-54:2334F, CHECCHI S.: "Derivatives of 5-aminopyrazole. IV. Synthesis of heterocyclic derivatives" page 2332; XP002970050
CHEMICAL ABSTRACTS, vol. 52, no. 3-4, 1958, Columbus, Ohio, US; abstract no. 52:2021F-I, CHECCHI S.: "5-Aminopyrazole derivatives. III. Acids of pyrazopyrimidine, pyrazopyridone, pyrazopyridine and some derivatives" page 2021; XP002970051
See also references of EP 1505068A4
TAKAMIZAWA A.: "Studies on pyrimidine derivatives and related compounds. LIX. Syntheses of 2,3-dihydro-1H-pyrarolo(5,1-b)purin-2-ones", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 16, no. 11, 1968, pages 2195 - 2199, XP002970048
BARTROLI J.: "New azole antifungals. 2. Synthesis and antifungal activity of heterocyclecarboxamide derivatives of 3-amino-2-aryl-1-azolyl-2-butanol", JOURNAL OF MEDICINAL CHEMISTRY, vol. 41, no. 11, 1998, pages 1855 - 1868, XP001121008
NOVINSON T.: "Synthesis and antifungal properties of certain 7-alkylaminopyrazolo(1,5-a)pyrimidines", JOURNAL OF MEDICINAL CHEMISTRY, vol. 20, no. 2, 1977, pages 296 - 299, XP002970049
MUSTAZZA C.: "Synthesis of pyrazolo(1,5-a)-, 1,2,4-triazolo(1,5-a)- and imidazo(1,2-a)pyrimidines related to zaleplon, a new drug for the treatment of insomnia", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 38, no. 5, 2001, pages 1119 - 1129, XP002963286
CHEMICAL ABSTRACTS, vol. 54, no. 1-3, 1960, Columbus, Ohio, US; abstract no. 54:2332I-54:2334F, CHECCHI S.: "Derivatives of 5-aminopyrazole. IV. Synthesis of heterocyclic derivatives" page 2332; XP002970050
CHEMICAL ABSTRACTS, vol. 52, no. 3-4, 1958, Columbus, Ohio, US; abstract no. 52:2021F-I, CHECCHI S.: "5-Aminopyrazole derivatives. III. Acids of pyrazopyrimidine, pyrazopyridone, pyrazopyridine and some derivatives" page 2021; XP002970051
See also references of EP 1505068A4
Attorney, Agent or Firm:
Yamamoto, Shusaku (Crystal Tower 2-27, Shiromi 1-chome, Chuo-k, Osaka-shi Osaka, JP)
Download PDF:
Previous Patent: NITROSATED IMIDAZOPYRIDINES
Next Patent: TRIARYL-OXY-ARYL-SPIRO-PYRIMIDINE-2, 4, 6-TRIONE METALLOPROTEINASE INHIBITORS
Next Patent: TRIARYL-OXY-ARYL-SPIRO-PYRIMIDINE-2, 4, 6-TRIONE METALLOPROTEINASE INHIBITORS