Title:
PANCREATIC ENDOCRINE CELL INDICATOR AND UTILIZATION OF SAME
Document Type and Number:
WIPO Patent Application WO/2011/013703
Kind Code:
A1
Abstract:
Disclosed is a pancreatic endocrine cell indicator comprising a modified polypeptide, in which a metal chelator is attached exclusively to an amino acid that is located at a site other than the somatostatin receptor-binding active site in a polypeptide selected from the group consisting of somatostatin and somatostatin analogs, and a radioactive metal nuclide that is held by said metal chelator. Thus, a novel pancreatic endocrine cell indicator can be provided.
Inventors:
WATANABE YASUYOSHI (JP)
SAKO TAKEO (JP)
HASEGAWA KOKI (JP)
KANAYAMA YOUSUKE (JP)
KATAOKA YOUSUKE (JP)
SAKO TAKEO (JP)
HASEGAWA KOKI (JP)
KANAYAMA YOUSUKE (JP)
KATAOKA YOUSUKE (JP)
Application Number:
PCT/JP2010/062701
Publication Date:
February 03, 2011
Filing Date:
July 28, 2010
Export Citation:
Assignee:
RIKEN (JP)
WATANABE YASUYOSHI (JP)
SAKO TAKEO (JP)
HASEGAWA KOKI (JP)
KANAYAMA YOUSUKE (JP)
KATAOKA YOUSUKE (JP)
WATANABE YASUYOSHI (JP)
SAKO TAKEO (JP)
HASEGAWA KOKI (JP)
KANAYAMA YOUSUKE (JP)
KATAOKA YOUSUKE (JP)
International Classes:
A61K51/00; A61K38/22; G01N33/53; G01N33/531; G01N33/534
Foreign References:
| JP2003504395A | 2003-02-04 | |||
| JP2005514335A | 2005-05-19 | |||
| JP2005068046A | 2005-03-17 | |||
| JP2007505915A | 2007-03-15 |
Other References:
ANGEW. CHEM. INT. ED., vol. 47, 2008, pages 102 - 105, XP008152513
"Shushu no y-Sen Hoshutsukaku o Mochiita Soki Shikkan Shindan Probe Kaihatsu to Compton Camera ni yoru Fukusu Kakushu Doji Imaging ni Kansuru Kenkyu", HEISEI 20 NENDO SOKATSU KENKYU HOKOKUSHO, April 2009 (2009-04-01), pages 10 - 13, XP008152516
"Symposium on Biofunctional Chemistry,", vol. 22, 2007, article "Abstracts", pages: 292 - 293, XP008152518
SHUNKI NENKAI KOEN YOKOSHU II, THE CHEMICAL SOCIETY OF JAPAN DAI 87, vol. 87, 2007, pages 1244, XP008152519
See also references of EP 2460542A4
BULTER AE, DIABETES, vol. 52, 2003, pages 102 - 110
YOON KH, J. CLIN. ENDOCRINOL. METAB., vol. 88, 2003, pages 2300 - 2308
DONATH MY; HALBAN PA., DIABETOLOGIA, vol. 47, no. 3, 2004, pages 581 - 589
RHODES CJ., SCIENCE, vol. 307, no. 5708, 2005, pages 380 - 384
KUNG MP; HOU C; KUNG HF ET AL., J. NUCLEAR MEDICINE, vol. 49, 2008, pages 1171 - 1176
SIMPSON NR; SOUZA F; HARRIS P ET AL., NUCLEAR MEDICINE AND BIOLOGY, vol. 33, no. 7, 2006, pages 855 - 864
SIMPSON NR; SOUZA F; HARRIS P ET AL., JOURNAL OF CLINICAL INVESTIGATION, vol. 1, no. 6, 2006, pages 1506 - 1513
A. SCHMITZ; C.-Y. SHIUE; Q. FENG ET AL., NUCLEAR MEDICINE AND BIOLOGY, vol. 31, no. 4, 2004, pages 483 - 491
B. WANGLER; S. SCHNEIDER; O. THEW ET AL., NUCLEAR MEDICINE AND BIOLOGY, vol. 31, no. 5, 2004, pages 639 - 647
TANAKA ET AL., ANGEW. CHEM. INT. ED., vol. 47, 2008, pages 102 - 105
STORCH ET AL., THE JOURNAL OF NUCLEAR MEDICINE, vol. 46, no. 9, 2005
REUBI ET AL., EUROPEAN JOURNAL OF NUCLEAR MEDICINE, vol. 27, no. 3, 2000
GARRISON ET AL., BIOCONJUGATE CHEM., vol. 19, 2008, pages 1803 - 1812
TETRAHEDRON LETTERS, vol. 44, 2003, pages 2393 - 2396
QI J; LEAHY R: "Resolution and noise properties of MAP reconstruction for fully 3-D PET", IEEE TRANS MED IMAG, vol. 19, 2000, pages 493 - 506, XP002549082, DOI: doi:10.1109/42.870259
"Shushu no y-Sen Hoshutsukaku o Mochiita Soki Shikkan Shindan Probe Kaihatsu to Compton Camera ni yoru Fukusu Kakushu Doji Imaging ni Kansuru Kenkyu", HEISEI 20 NENDO SOKATSU KENKYU HOKOKUSHO, April 2009 (2009-04-01), pages 10 - 13, XP008152516
"Symposium on Biofunctional Chemistry,", vol. 22, 2007, article "Abstracts", pages: 292 - 293, XP008152518
SHUNKI NENKAI KOEN YOKOSHU II, THE CHEMICAL SOCIETY OF JAPAN DAI 87, vol. 87, 2007, pages 1244, XP008152519
See also references of EP 2460542A4
BULTER AE, DIABETES, vol. 52, 2003, pages 102 - 110
YOON KH, J. CLIN. ENDOCRINOL. METAB., vol. 88, 2003, pages 2300 - 2308
DONATH MY; HALBAN PA., DIABETOLOGIA, vol. 47, no. 3, 2004, pages 581 - 589
RHODES CJ., SCIENCE, vol. 307, no. 5708, 2005, pages 380 - 384
KUNG MP; HOU C; KUNG HF ET AL., J. NUCLEAR MEDICINE, vol. 49, 2008, pages 1171 - 1176
SIMPSON NR; SOUZA F; HARRIS P ET AL., NUCLEAR MEDICINE AND BIOLOGY, vol. 33, no. 7, 2006, pages 855 - 864
SIMPSON NR; SOUZA F; HARRIS P ET AL., JOURNAL OF CLINICAL INVESTIGATION, vol. 1, no. 6, 2006, pages 1506 - 1513
A. SCHMITZ; C.-Y. SHIUE; Q. FENG ET AL., NUCLEAR MEDICINE AND BIOLOGY, vol. 31, no. 4, 2004, pages 483 - 491
B. WANGLER; S. SCHNEIDER; O. THEW ET AL., NUCLEAR MEDICINE AND BIOLOGY, vol. 31, no. 5, 2004, pages 639 - 647
TANAKA ET AL., ANGEW. CHEM. INT. ED., vol. 47, 2008, pages 102 - 105
STORCH ET AL., THE JOURNAL OF NUCLEAR MEDICINE, vol. 46, no. 9, 2005
REUBI ET AL., EUROPEAN JOURNAL OF NUCLEAR MEDICINE, vol. 27, no. 3, 2000
GARRISON ET AL., BIOCONJUGATE CHEM., vol. 19, 2008, pages 1803 - 1812
TETRAHEDRON LETTERS, vol. 44, 2003, pages 2393 - 2396
QI J; LEAHY R: "Resolution and noise properties of MAP reconstruction for fully 3-D PET", IEEE TRANS MED IMAG, vol. 19, 2000, pages 493 - 506, XP002549082, DOI: doi:10.1109/42.870259
Attorney, Agent or Firm:
HARAKENZO WORLD PATENT & TRADEMARK (JP)
Patent business corporation Hara [Kenzo] international patent firm (JP)
Patent business corporation Hara [Kenzo] international patent firm (JP)
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