Title:
PARP INHIBITOR CONTAINING PIPERAZINE STRUCTURE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/222921
Kind Code:
A1
Abstract:
Provided are a PARP inhibitor containing a piperazine structure, a preparation method therefor and the pharmaceutical use thereof. Specifically, provided are compounds represented by general formulas (1), (2), (3), (4) and (5) and/or a pharmaceutically acceptable salt thereof, and a composition containing the compounds represented by the general formulas (1), (2), (3), (4) and (5) and/or the pharmaceutically acceptable salt thereof, the preparation method, and the use thereof as a PARP inhibitor in the preparation of an anti-tumor drug.
Inventors:
XIE YULI (CN)
LV YONGCONG (CN)
QIAN LIHUI (CN)
FAN HOUXING (CN)
LV YONGCONG (CN)
QIAN LIHUI (CN)
FAN HOUXING (CN)
Application Number:
PCT/CN2022/087652
Publication Date:
October 27, 2022
Filing Date:
April 19, 2022
Export Citation:
Assignee:
WIGEN BIOMEDICINE TECH SHANGHAI CO LTD (CN)
International Classes:
C07D471/04; A61K31/496; A61K31/4965; A61K31/498; A61K31/4985; A61K31/501; A61K31/506; A61K31/5383; A61P35/00; C07D401/14; C07D498/04
Domestic Patent References:
| WO2021013735A1 | 2021-01-28 | |||
| WO2009053373A1 | 2009-04-30 | |||
| WO2010111626A2 | 2010-09-30 |
Foreign References:
| CN102341394A | 2012-02-01 | |||
| CN107849040A | 2018-03-27 | |||
| CN202110439238A | 2021-04-22 |
Other References:
LASTRA CA ET AL., CURR PHARM DES., vol. 13, no. 9, 2007, pages 933 - 962
"March, ADVANCED ORGANIC CHEMISTRY", 1992, WILEY
CAREYSUNDBERG: "ADVANCED ORGANIC CHEMISTRY", vol. A,B, 2000, PLENUM
GREENWUTS: "PROTECTIVE GROUPS IN ORGANIC SYNTHESIS", 1999, WILEY
"March, ADVANCED ORGANIC CHEMISTRY", 1992, WILEY
CAREYSUNDBERG: "ADVANCED ORGANIC CHEMISTRY", vol. A,B, 2000, PLENUM
GREENWUTS: "PROTECTIVE GROUPS IN ORGANIC SYNTHESIS", 1999, WILEY
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
Download PDF:
Previous Patent: CHARACTERIZATION AND APPLICATION OF NOVEL HIGH-TEMPERATURE ARGONAUTE PROTEIN
Next Patent: VOICE SIGNAL PROCESSING METHOD AND APPARATUS
Next Patent: VOICE SIGNAL PROCESSING METHOD AND APPARATUS