Title:
PD-L2 MOLECULES: PD-1 LIGANDS AND USES THEREFOR
Document Type and Number:
WIPO Patent Application WO2002000692
Kind Code:
A3
Abstract:
The invention provides isolated nucleic acid molecules, designated PD-L2 nucleic acid molecules, which encode novel B7-related molecules which are ligands for PD-1. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PD-L2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PD-L2 gene has been introduced or disrupted. The invention further provides isolated PD-L2 polypeptides, fusion proteins, antigenic peptides and anti-PD-L2 antibodies. The invention still further provides methods for promoting or inhibiting the interaction between PD-L2 and PD-1. Diagnostic and treatment methods utilizing compositions of the invention are also provided.
Inventors:
FREEMAN GORDON
CHERNOVA IRENE
CHERNOVA TATYANA
MALENKOVICH NELLY
WOOD CLIVE
LATCHMAN YVETTE
SHARPE ARLENE H
CHERNOVA IRENE
CHERNOVA TATYANA
MALENKOVICH NELLY
WOOD CLIVE
LATCHMAN YVETTE
SHARPE ARLENE H
Application Number:
PCT/US2001/020858
Publication Date:
March 27, 2003
Filing Date:
June 28, 2001
Export Citation:
Assignee:
INST GENETICS LLC (US)
DANA FARBER CANCER INST INC (US)
BRIGHAM & WOMENS HOSPITAL (US)
DANA FARBER CANCER INST INC (US)
BRIGHAM & WOMENS HOSPITAL (US)
International Classes:
A61K39/00; A61K39/395; A61K48/00; A61P3/10; A61P11/06; A61P29/00; A61P31/00; A61P35/00; A61P37/00; A61P37/08; C07K14/705; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/12; C12P21/02; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/566; G01N33/573; G01N33/68; (IPC1-7): C12N15/12; C07K14/705; G01N33/50
Domestic Patent References:
| WO2001039722A2 | 2001-06-07 | |||
| WO2001014557A1 | 2001-03-01 | |||
| WO2002000730A2 | 2002-01-03 | |||
| WO2001094413A2 | 2001-12-13 | |||
| WO2002008279A2 | 2002-01-31 | |||
| WO2001083750A2 | 2001-11-08 |
Other References:
DONG H ET AL: "B7-H1, A THIRD MEMBER OF THE B7 FAMILY, CO-STIMULATES T-CELL PROLIFERATION AND INTERLEUKIN-10 SECRETION", NATURE MEDICINE, NATURE PUBLISHING, CO, US, vol. 5, no. 12, December 1999 (1999-12-01), pages 1635 - 1639, XP002942544, ISSN: 1078-8956
FREEMAN G J ET AL: "The B7 homologue, PD-L is the ligand of the PD-1 immunoinhibitory receptor", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, BETHESDA, MD, US, vol. 14, no. 6, May 2000 (2000-05-01), pages a1170, XP002202702, ISSN: 0892-6638
FREEMAN G ET AL: "ENGAGEMENT OF THE PD-1 IMMUNOINHIBITORY RECEPTOR BY A NOVEL B7 FAMILY MEMBER LEADS TO NEGATIVE REGULATION OF LYMPHOCYTE ACTIVATION", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 192, no. 7, 2 October 2000 (2000-10-02), pages 1027 - 1034, XP000971650, ISSN: 0022-1007
TSENG SU-YI ET AL: "B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 193, no. 7, 2 April 2001 (2001-04-02), pages 839 - 845, XP002193883, ISSN: 0022-1007
LATCHMAN YVETTE ET AL: "PD-L2 is a second ligand for PD-1 and inhibits T cell activation", NATURE IMMUNOLOGY, NATURE PUBLISHING GROUP,, GB, vol. 2, no. 3, March 2001 (2001-03-01), pages 261 - 268, XP001064842, ISSN: 1529-2908
AGATA Y ET AL: "EXPRESSION OF THE PD-1 ANTIGEN ON THE SURFACE OF STIMULATED MOUSE T AND B LYMPHOCYTES", INTERNATIONAL IMMUNOLOGY, OXFORD UNIVERSITY PRESS, GB, vol. 8, no. 5, May 1996 (1996-05-01), pages 765 - 772, XP000971773, ISSN: 0953-8178
FREEMAN G J ET AL: "The B7 homologue, PD-L is the ligand of the PD-1 immunoinhibitory receptor", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, BETHESDA, MD, US, vol. 14, no. 6, May 2000 (2000-05-01), pages a1170, XP002202702, ISSN: 0892-6638
FREEMAN G ET AL: "ENGAGEMENT OF THE PD-1 IMMUNOINHIBITORY RECEPTOR BY A NOVEL B7 FAMILY MEMBER LEADS TO NEGATIVE REGULATION OF LYMPHOCYTE ACTIVATION", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 192, no. 7, 2 October 2000 (2000-10-02), pages 1027 - 1034, XP000971650, ISSN: 0022-1007
TSENG SU-YI ET AL: "B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 193, no. 7, 2 April 2001 (2001-04-02), pages 839 - 845, XP002193883, ISSN: 0022-1007
LATCHMAN YVETTE ET AL: "PD-L2 is a second ligand for PD-1 and inhibits T cell activation", NATURE IMMUNOLOGY, NATURE PUBLISHING GROUP,, GB, vol. 2, no. 3, March 2001 (2001-03-01), pages 261 - 268, XP001064842, ISSN: 1529-2908
AGATA Y ET AL: "EXPRESSION OF THE PD-1 ANTIGEN ON THE SURFACE OF STIMULATED MOUSE T AND B LYMPHOCYTES", INTERNATIONAL IMMUNOLOGY, OXFORD UNIVERSITY PRESS, GB, vol. 8, no. 5, May 1996 (1996-05-01), pages 765 - 772, XP000971773, ISSN: 0953-8178
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