Title:
PEGYLATED LIPID CONTAINING LYSINE CORE
Document Type and Number:
WIPO Patent Application WO/2024/067816
Kind Code:
A1
Abstract:
The present invention relates to the field of drug delivery, and specifically relates to a pegylated lipid containing a lysine core and capable of being used as a drug carrier component, a lipid composition containing the pegylated lipid, and an LNP-pharmaceutical composition and a preparation thereof and a use thereof. According to the present invention, the pegylated lipid containing the lysine core is more stable in vivo, can be used for preparing a lipid composition and a lipid pharmaceutical composition, and has the advantages of longer systemic circulation time, high biocompatibility, low toxicity, high encapsulation efficiency, high delivery efficiency and the like.
Inventors:
WENG WENGUI (CN)
LIU CHAO (CN)
WEI GUOHUA (CN)
WANG AILAN (CN)
WANG LINLIN (CN)
LIN SHENG (CN)
ZHENG ZHONGZHI (CN)
YUAN JINCHUN (CN)
LIU CHAO (CN)
WEI GUOHUA (CN)
WANG AILAN (CN)
WANG LINLIN (CN)
LIN SHENG (CN)
ZHENG ZHONGZHI (CN)
YUAN JINCHUN (CN)
Application Number:
PCT/CN2023/122654
Publication Date:
April 04, 2024
Filing Date:
September 28, 2023
Export Citation:
Assignee:
XIAMEN SINOPEG BIOTECH CO LTD (CN)
International Classes:
C08G65/00; A61K9/127; C07C229/26
Domestic Patent References:
| WO2019243825A1 | 2019-12-26 | |||
| WO2021226597A2 | 2021-11-11 |
Foreign References:
| KR20150061946A | 2015-06-05 | |||
| CN105188673A | 2015-12-23 | |||
| CN115052635A | 2022-09-13 | |||
| CN113402405A | 2021-09-17 |
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