Title:
PEPTIDE-BASED COMPOUNDS FOR TARGETING INTERGIN RECEPTORS
Document Type and Number:
WIPO Patent Application WO2003006491
Kind Code:
A3
Abstract:
The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors.
Inventors:
CUTHBERTSON ALAN (NO)
INDREVOLL BAARD (NO)
SOLBAKKEN MAGNE (NO)
ARCHER COLIN MILL (GB)
WADSWORTH HARRY JOHN (GB)
ENGELL TORGRIM (NO)
INDREVOLL BAARD (NO)
SOLBAKKEN MAGNE (NO)
ARCHER COLIN MILL (GB)
WADSWORTH HARRY JOHN (GB)
ENGELL TORGRIM (NO)
Application Number:
PCT/NO2002/000250
Publication Date:
December 24, 2003
Filing Date:
July 08, 2002
Export Citation:
Assignee:
AMERSHAM HEALTH AS (NO)
CUTHBERTSON ALAN (NO)
INDREVOLL BAARD (NO)
SOLBAKKEN MAGNE (NO)
ARCHER COLIN MILL (GB)
WADSWORTH HARRY JOHN (GB)
ENGELL TORGRIM (NO)
CUTHBERTSON ALAN (NO)
INDREVOLL BAARD (NO)
SOLBAKKEN MAGNE (NO)
ARCHER COLIN MILL (GB)
WADSWORTH HARRY JOHN (GB)
ENGELL TORGRIM (NO)
International Classes:
A61K47/65; A61K49/00; A61K49/04; A61K51/00; A61K51/08; A61P1/02; A61P1/04; A61P9/00; A61P9/08; A61P9/10; A61P15/00; A61P17/00; A61P17/06; A61P19/02; A61P27/02; A61P29/00; A61P35/00; A61P35/04; C07K7/00; C07K7/06; C07K14/745; A61K38/00; (IPC1-7): A61K47/48; A61K49/00; A61K51/08
Domestic Patent References:
| WO2001077145A2 | 2001-10-18 | |||
| WO1993012819A1 | 1993-07-08 | |||
| WO2002020610A2 | 2002-03-14 | |||
| WO1999051638A1 | 1999-10-14 |
Foreign References:
| US5888474A | 1999-03-30 |
Other References:
RAJOPADHYE M ET AL: "Synthesis, evaluation and Tc-99m complexation of a hydrazinonicotinyl conjugate of a gp IIb/IIIa antagonist cyclic peptide for the detection of deep vein thrombosis", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 7, no. 8, 22 April 1997 (1997-04-22), pages 955 - 960, XP004136163, ISSN: 0960-894X
RAJOPADHYE M ET AL: "Synthesis and technetum-99M labeling of cyclic GP IIB/IIIA receptor antagonists conjugated to 4,5-bis(mercaptoacetamido)-pentanoic acid (MAPT)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 6, no. 15, 6 August 1996 (1996-08-06), pages 1737 - 1740, XP004135593, ISSN: 0960-894X
PEARSON D A ET AL: "THROMBUS IMAGING USING TECHNETIUM-99M-LABELED HIGH-POTENCY GPIIB/IIIA RECEPTOR ANTAGONISTS. CHEMISTRY AND INITIAL BIOLOGICAL STUDIES", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 39, no. 7, 1996, pages 1372 - 1382, XP002061485, ISSN: 0022-2623
HARRIS T D ET AL: "Tc-99m-labeled fibrinogen receptor antagonists: design and synthesis of cyclic RGD peptides for the detection of thrombi", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 6, no. 15, 6 August 1996 (1996-08-06), pages 1741 - 1746, XP004135594, ISSN: 0960-894X
LIU SHUANG ET AL: "99mTc-labeling of a hydrazinonicotinamide-conjugated vitronectin receptor antagonist useful for imaging tumors", BIOCONJUGATE CHEMISTRY, vol. 12, no. 4, 6 July 2001 (2001-07-06), &, pages 624 - 629, XP002259284, ISSN: 1043-1802
SIVOLAPENKO G B ET AL: "Imaging of metastatic melanoma utilising a technetium-99m labelled RGD-containing synthetic peptide", EUROPEAN JOURNAL OF NUCLEAR MEDICINE 1998 GERMANY, vol. 25, no. 10, 1998, pages 1383 - 1389, XP002259285, ISSN: 0340-6997
UEHARA T ET AL: "The integrity of the disulfide bond in a cyclic somatostatin analog during <99m>tc complexation reactions - Preparation and preliminary evaluation", NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, US, vol. 26, no. 8, November 1999 (1999-11-01), pages 883 - 890, XP004185286, ISSN: 0969-8051
HALLAHAN D E ET AL: "Targeting drug delivery to radiation-induced neoantigens in tumor microvasculature", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 74, no. 1-3, 6 July 2001 (2001-07-06), pages 183 - 191, XP004297523, ISSN: 0168-3659
MERRIFIELD R B: "SOLID PHASE PEPTIDE SYNTHESIS. I. THE SYNTHESIS OF A TETRAPEPTIDE", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 85, 20 July 1963 (1963-07-20), pages 2149 - 2154, XP000994867, ISSN: 0002-7863
RAJOPADHYE M ET AL: "Synthesis and technetum-99M labeling of cyclic GP IIB/IIIA receptor antagonists conjugated to 4,5-bis(mercaptoacetamido)-pentanoic acid (MAPT)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 6, no. 15, 6 August 1996 (1996-08-06), pages 1737 - 1740, XP004135593, ISSN: 0960-894X
PEARSON D A ET AL: "THROMBUS IMAGING USING TECHNETIUM-99M-LABELED HIGH-POTENCY GPIIB/IIIA RECEPTOR ANTAGONISTS. CHEMISTRY AND INITIAL BIOLOGICAL STUDIES", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 39, no. 7, 1996, pages 1372 - 1382, XP002061485, ISSN: 0022-2623
HARRIS T D ET AL: "Tc-99m-labeled fibrinogen receptor antagonists: design and synthesis of cyclic RGD peptides for the detection of thrombi", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 6, no. 15, 6 August 1996 (1996-08-06), pages 1741 - 1746, XP004135594, ISSN: 0960-894X
LIU SHUANG ET AL: "99mTc-labeling of a hydrazinonicotinamide-conjugated vitronectin receptor antagonist useful for imaging tumors", BIOCONJUGATE CHEMISTRY, vol. 12, no. 4, 6 July 2001 (2001-07-06), &, pages 624 - 629, XP002259284, ISSN: 1043-1802
SIVOLAPENKO G B ET AL: "Imaging of metastatic melanoma utilising a technetium-99m labelled RGD-containing synthetic peptide", EUROPEAN JOURNAL OF NUCLEAR MEDICINE 1998 GERMANY, vol. 25, no. 10, 1998, pages 1383 - 1389, XP002259285, ISSN: 0340-6997
UEHARA T ET AL: "The integrity of the disulfide bond in a cyclic somatostatin analog during <99m>tc complexation reactions - Preparation and preliminary evaluation", NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, US, vol. 26, no. 8, November 1999 (1999-11-01), pages 883 - 890, XP004185286, ISSN: 0969-8051
HALLAHAN D E ET AL: "Targeting drug delivery to radiation-induced neoantigens in tumor microvasculature", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 74, no. 1-3, 6 July 2001 (2001-07-06), pages 183 - 191, XP004297523, ISSN: 0168-3659
MERRIFIELD R B: "SOLID PHASE PEPTIDE SYNTHESIS. I. THE SYNTHESIS OF A TETRAPEPTIDE", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 85, 20 July 1963 (1963-07-20), pages 2149 - 2154, XP000994867, ISSN: 0002-7863
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