Title:
PEPTIDE FOR INHIBITING VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR
Document Type and Number:
WIPO Patent Application WO/2014/034922
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a VEGFR2 inhibitor peptide that has high specificity and can be manufactured at low cost. The present invention provides a peptide containing the following amino acid sequences: Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11-Xaa12-Xaa13-Xaa14-Xaa15 (in the formula, Xaa2 is Val or a derivative thereof, Xaa6 is Asp or a derivative thereof, Xaa7 is Pro or a derivative thereof, Xaa8 is Trp or a derivative thereof, Xaa10 is Asn or a derivative thereof, Xaa11 is Gly or a derivative thereof, Xaa12 is Leu or a derivative thereof, and Xaa1, Xaa3-Xaa5, Xaa9 and Xaa13-Xaa15 are each independent and any amino acid or derivative thereof); or Xaa16-Xaa17-Xaa18-Xaa19-Xaa20-Xaa21-Xaa22-Xaa23-Xaa24-Xaa25-Xaa26-Xaa27-Xaa28-Xaa29-Xaa30 (in the formula, Xaa24 is His or a derivative thereof, Xaa25 is Pro or a derivative thereof, and Xaa16-Xaa23 and Xaa26-Xaa30 are any amino acid).
Inventors:
MURAKAMI HIROSHI (JP)
KAWAKAMI TAKASHI (JP)
ISHIZAWA TAKAHIRO (JP)
SUGA HIROAKI (JP)
REID PATRICK (JP)
KAWAKAMI TAKASHI (JP)
ISHIZAWA TAKAHIRO (JP)
SUGA HIROAKI (JP)
REID PATRICK (JP)
Application Number:
PCT/JP2013/073471
Publication Date:
March 06, 2014
Filing Date:
September 02, 2013
Export Citation:
Assignee:
UNIV TOKYO (JP)
PEPTIDREAM INC (JP)
PEPTIDREAM INC (JP)
International Classes:
C07K7/08; A61K38/00; A61P9/00; A61P35/00; A61P43/00
Domestic Patent References:
| WO2012017256A2 | 2012-02-09 | |||
| WO2012074130A1 | 2012-06-07 | |||
| WO2011049157A1 | 2011-04-28 | |||
| WO2007066627A1 | 2007-06-14 | |||
| WO2008117833A1 | 2008-10-02 | |||
| WO2012074129A1 | 2012-06-07 |
Foreign References:
| JP2006523608A | 2006-10-19 | |||
| JP2012510287A | 2012-05-10 | |||
| JP2004510784A | 2004-04-08 |
Other References:
DATABASE UNIPROT [online] 1 June 2003 (2003-06-01), KANEKO ET AL., XP008181789, retrieved from IBIS Database accession no. Q89TW4
DATABASE UNIPROT [online] 24 March 2009 (2009-03-24), MORAN ET AL.: "RECNAME: FULL=UPF0173 METAL-DEPENDENT HYDROLASE SPO297676", XP055244644, retrieved from NCBI Database accession no. Q5LP74
BINETRUY-TOURNAIRE ET AL.: "Identification of a Peptide Blocking Vascular Endothelial Growth Factor(VEGF)-Mediated Angiogenesis", THE EMBO JOURMAL, vol. 19, no. 7, 2000, pages 1525 - 1533, XP002179245
ISIZAWA T ET AL.: "TRAP Display:A High-Speed Selection Method for the Generation of Functional Polypeptides", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 135, 2013, pages 5433 - 5440, XP055242138
MASABUMI SHIBUYA, NIPPON YAKURIGAKU ZASSHI (FOLIA PHARMACOL. JPN., vol. 122, 2003, pages 498 - 503
Q.T. HO ET AL., INT. J. BIOCHEM. CELL BIOL., vol. 39, 2007, pages 1349 - 57
ZHANG, J. ET AL., NAT. REV. CANCER, vol. 9, 2008, pages 28 - 39
SCOTT, A. M. ET AL., NAT. REV. CANCER, vol. 12, 2012, pages 278 - 87
H. MURAKAMI; H. SAITO; H. SUGA, CHEMISTRY & BIOLOGY, vol. 10, 2003, pages 655 - 662
H. MURAKAMI; D. KOUROUKLIS; H. SUGA, CHEMISTRY & BIOLOGY, vol. 10, 2003, pages 1077 - 1084
H. MURAKAMI; A. OHTA; H. ASHIGAI; H. SUGA: "The flexizyme system: a highly flexible tRNA aminoacylation tool for the synthesis of nonnatural peptides", NATURE METHODS, vol. 3, 2006, pages 357 - 359
N. NIWA; Y. YAMAGISHI; H. MURAKAMI; H. SUGA: "A flexizyme that selectively charges amino acids activated by a water-friendly leaving group", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, 2009, pages 3892 - 3894
KAWAKAMI, T. ET AL., NATURE CHEMICAL BIOLOGY, vol. 5, 2009, pages 888 - 890
YAMAGISHI, Y. ET AL., CHEMBIOCHEM, vol. 10, 2009, pages 1469 - 1472
SAKO, Y. ET AL., JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 130, 2008, pages 7932 - 7934
GOTO, Y. ET AL., ACS CHEMICAL BIOLOGY, vol. 3, 2008, pages 120 - 129
KAWAKAMI T ET AL., CHEMISTRY & BIOLOGY, vol. 15, 2008, pages 32 - 42
T. ISHIZAWA; T. KAWAKAMI; P. C. REID; H. MURAKAMI, J. AM. CHEM. SOC., vol. 135, 2013, pages 5433 - 5440
H. MURAKAMI; A. OHTA; H. ASHIGAI; H. SUGA, NATURE METHODS, vol. 3, 2006, pages 357 - 359
DATABASE UNIPROT [online] 24 March 2009 (2009-03-24), MORAN ET AL.: "RECNAME: FULL=UPF0173 METAL-DEPENDENT HYDROLASE SPO297676", XP055244644, retrieved from NCBI Database accession no. Q5LP74
BINETRUY-TOURNAIRE ET AL.: "Identification of a Peptide Blocking Vascular Endothelial Growth Factor(VEGF)-Mediated Angiogenesis", THE EMBO JOURMAL, vol. 19, no. 7, 2000, pages 1525 - 1533, XP002179245
ISIZAWA T ET AL.: "TRAP Display:A High-Speed Selection Method for the Generation of Functional Polypeptides", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 135, 2013, pages 5433 - 5440, XP055242138
MASABUMI SHIBUYA, NIPPON YAKURIGAKU ZASSHI (FOLIA PHARMACOL. JPN., vol. 122, 2003, pages 498 - 503
Q.T. HO ET AL., INT. J. BIOCHEM. CELL BIOL., vol. 39, 2007, pages 1349 - 57
ZHANG, J. ET AL., NAT. REV. CANCER, vol. 9, 2008, pages 28 - 39
SCOTT, A. M. ET AL., NAT. REV. CANCER, vol. 12, 2012, pages 278 - 87
H. MURAKAMI; H. SAITO; H. SUGA, CHEMISTRY & BIOLOGY, vol. 10, 2003, pages 655 - 662
H. MURAKAMI; D. KOUROUKLIS; H. SUGA, CHEMISTRY & BIOLOGY, vol. 10, 2003, pages 1077 - 1084
H. MURAKAMI; A. OHTA; H. ASHIGAI; H. SUGA: "The flexizyme system: a highly flexible tRNA aminoacylation tool for the synthesis of nonnatural peptides", NATURE METHODS, vol. 3, 2006, pages 357 - 359
N. NIWA; Y. YAMAGISHI; H. MURAKAMI; H. SUGA: "A flexizyme that selectively charges amino acids activated by a water-friendly leaving group", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, 2009, pages 3892 - 3894
KAWAKAMI, T. ET AL., NATURE CHEMICAL BIOLOGY, vol. 5, 2009, pages 888 - 890
YAMAGISHI, Y. ET AL., CHEMBIOCHEM, vol. 10, 2009, pages 1469 - 1472
SAKO, Y. ET AL., JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 130, 2008, pages 7932 - 7934
GOTO, Y. ET AL., ACS CHEMICAL BIOLOGY, vol. 3, 2008, pages 120 - 129
KAWAKAMI T ET AL., CHEMISTRY & BIOLOGY, vol. 15, 2008, pages 32 - 42
T. ISHIZAWA; T. KAWAKAMI; P. C. REID; H. MURAKAMI, J. AM. CHEM. SOC., vol. 135, 2013, pages 5433 - 5440
H. MURAKAMI; A. OHTA; H. ASHIGAI; H. SUGA, NATURE METHODS, vol. 3, 2006, pages 357 - 359
Attorney, Agent or Firm:
INABA, Yoshiyuki et al. (JP)
Yoshiyuki Inaba (JP)
Yoshiyuki Inaba (JP)
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