Title:
PEPTIDE INTERACTING WITH TOLL-LIKE RECEPTOR 2 AND THE COMPOSITION COMPRISING THE SAME
Document Type and Number:
WIPO Patent Application WO/2021/139766
Kind Code:
A1
Abstract:
Provided herein are peptide fragments of Amuc 1100 and the use thereof. The peptide is shown to be a ligand to activate TLR2 and is used to treat obesity and the related disease or condition. The peptide is further used in the treatment of intestinal cancer, promoting immune response, and intestinal epithelial barrier dysfunction.
Inventors:
HUANG CHIH-HUNG (CN)
CHANG PU-CHIEH (CN)
CHANG PU-CHIEH (CN)
Application Number:
PCT/CN2021/070859
Publication Date:
July 15, 2021
Filing Date:
January 08, 2021
Export Citation:
Assignee:
HUANG CHIH HUNG (CN)
International Classes:
C07K14/195; A61K39/00; C12N1/22
Domestic Patent References:
| WO2016177797A1 | 2016-11-10 |
Foreign References:
| US20180311310A1 | 2018-11-01 | |||
| CN110559424A | 2019-12-13 |
Other References:
HUBERT PLOVIER, AMANDINE EVERARD, CÉLINE DRUART, CLARA DEPOMMIER, MATTHIAS VAN HUL, LUCIE GEURTS, JULIEN CHILLOUX, NOORA OTTMAN, T: "A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice", NATURE MEDICINE, NATURE PUB. CO, NEW YORK, vol. 23, no. 1, 1 January 2017 (2017-01-01), New York, pages 107 - 113, XP055585315, ISSN: 1078-8956, DOI: 10.1038/nm.4236
FORATO ANHÊ FERNANDO, ANDRÉ MARETTE: "A microbial protein that alleviates metabolic syndrome", NATURE MEDICINE, vol. 23, no. 1, 1 January 2017 (2017-01-01), pages 11 - 12, XP055815031
OTTMAN NOORA, REUNANEN JUSTUS, MEIJERINK MARJOLEIN, PIETILA TAIJA E, KAINULAINEN VEERA, KLIEVINK JUDITH, HUUSKONEN LAURA, AALVINK : "Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, UNITED STATES, 1 January 2017 (2017-01-01), United States, pages e0173004 - e0173004, XP055815035, Retrieved from the Internet [retrieved on 20210617], DOI: 10.1371/journal.pone.0173004
ASHRAFIAN FATEMEH, BEHROUZI AVA, SHAHRIARY AREFEH, AHMADI BADI SARA, DAVARI MEHDI, KHATAMI SHOHRE, JAMNANI FATEMEH RAHIMI, FATEH A: "Gastroenterology and Hepatology From Bed to Bench Comparative study of effect of Akkermansia muciniphila and its extracellular vesicles on toll-like receptors and tight junction", GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 12, no. 2, 1 January 2019 (2019-01-01), pages 163 - 168, XP055826621
NAITO Y, ET AL.: "A next-generation beneficial microbe: Akkermansia muciniphila", J CLIN BIOCHEM NUTR., vol. 63, no. 1, 1 January 2018 (2018-01-01), pages 33 - 35, XP055804715, DOI: 10.3164/jcbn.18-57
MENG XIN, WANG WENCHENG, LAN TIANQI, YANG WANXIN, YU DAHAI, FANG XUEXUN, WU HAO: "A Purified Aspartic Protease from Akkermansia Muciniphila Plays an Important Role in Degrading Muc2", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. 1, 20 December 2019 (2019-12-20), XP055826622, DOI: 10.3390/ijms21010072
See also references of EP 4087859A4
FORATO ANHÊ FERNANDO, ANDRÉ MARETTE: "A microbial protein that alleviates metabolic syndrome", NATURE MEDICINE, vol. 23, no. 1, 1 January 2017 (2017-01-01), pages 11 - 12, XP055815031
OTTMAN NOORA, REUNANEN JUSTUS, MEIJERINK MARJOLEIN, PIETILA TAIJA E, KAINULAINEN VEERA, KLIEVINK JUDITH, HUUSKONEN LAURA, AALVINK : "Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, UNITED STATES, 1 January 2017 (2017-01-01), United States, pages e0173004 - e0173004, XP055815035, Retrieved from the Internet
ASHRAFIAN FATEMEH, BEHROUZI AVA, SHAHRIARY AREFEH, AHMADI BADI SARA, DAVARI MEHDI, KHATAMI SHOHRE, JAMNANI FATEMEH RAHIMI, FATEH A: "Gastroenterology and Hepatology From Bed to Bench Comparative study of effect of Akkermansia muciniphila and its extracellular vesicles on toll-like receptors and tight junction", GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 12, no. 2, 1 January 2019 (2019-01-01), pages 163 - 168, XP055826621
NAITO Y, ET AL.: "A next-generation beneficial microbe: Akkermansia muciniphila", J CLIN BIOCHEM NUTR., vol. 63, no. 1, 1 January 2018 (2018-01-01), pages 33 - 35, XP055804715, DOI: 10.3164/jcbn.18-57
MENG XIN, WANG WENCHENG, LAN TIANQI, YANG WANXIN, YU DAHAI, FANG XUEXUN, WU HAO: "A Purified Aspartic Protease from Akkermansia Muciniphila Plays an Important Role in Degrading Muc2", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. 1, 20 December 2019 (2019-12-20), XP055826622, DOI: 10.3390/ijms21010072
See also references of EP 4087859A4
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
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