Title:
PEPTIDE MODIFIED WITH GLUT1-LIGAND-MODIFIED NON-CHARGED HYDROPHILIC POLYMER CLEAVABLY UNDER REDUCTIVE ENVIRONMENT OR LOW-PH ENVIRONMENT, AND ANTIBODY COMPRISING SAID PEPTIDE
Document Type and Number:
WIPO Patent Application WO/2021/230375
Kind Code:
A1
Abstract:
The present invention relates to a peptide which is modified with a non-charged hydrophilic polymer segment modified with a GLUT1 ligand, in which the peptide is modified in a manner such that the peptide can be cleaved from the segment under a reductive environment or a low-pH environment. The present invention also provides an antibody comprising the peptide moiety.
Inventors:
KATAOKA KAZUNORI (JP)
ANRAKU YASUTAKA (JP)
XIE JINBING (JP)
ANRAKU YASUTAKA (JP)
XIE JINBING (JP)
Application Number:
PCT/JP2021/018506
Publication Date:
November 18, 2021
Filing Date:
May 14, 2021
Export Citation:
Assignee:
KAWASAKI INST OF INDUSTRIAL PROMOTION (JP)
International Classes:
C07K16/18; A61K47/54; A61K47/68; C07K16/28
Domestic Patent References:
| WO2017002979A1 | 2017-01-05 |
Other References:
KUN SHAO, YU ZHANG , NING DING , SHIXIAN HUANG , JIQIN WU , JIANFENG LI , CHUNFU YANG , QIBIN LENG , LIYA YE , JINNING LOU , LIPIN: "Functionalized Nanoscale Micelles with Brain Targeting Ability and Intercellular Microenvironment Biosensitivity for Anti-Intracranial Infection Applications", ADVANCED HEALTHCARE MATERIALS, vol. 4, no. 2, 28 January 2015 (2015-01-28), pages 291 - 330, XP055506061, DOI: 10.1002/adhm.201400214
LU LU; ZHAO XIAOJING; FU TIWEI; LI KE; HE YE; LUO ZHONG; DAI LIANGLIANG; ZENG RUI; CAI KAIYONG: "An iRGD-conjugated prodrug micelle with blood-brain-barrier penetrability for anti-glioma therapy", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 230, 3 December 2019 (2019-12-03), AMSTERDAM, NL , XP085965822, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2019.119666
LU LU; ZHAO XIAOJING; FU TIWEI; LI KE; HE YE; LUO ZHONG; DAI LIANGLIANG; ZENG RUI; CAI KAIYONG: "An iRGD-conjugated prodrug micelle with blood-brain-barrier penetrability for anti-glioma therapy", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 230, 3 December 2019 (2019-12-03), AMSTERDAM, NL , XP085965822, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2019.119666
Attorney, Agent or Firm:
OHNO Seiji et al. (JP)
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