Title:
PEPTIDE AND NUCLEIC ACID CODING THEREFOR FOR THE DETECTION, DIAGNOSIS AND THERAPY OF DISEASES OF THE NERVOUS SYSTEM
Document Type and Number:
WIPO Patent Application WO2001060844
Kind Code:
A3
Abstract:
The invention relates to a novel peptide, fusion proteins and polypeptides containing said peptide, test kits and a method for detecting the peptide, coding nucleic acids and pharmaceutical compositions which contain the peptide or are based on the coding nucleic acid. The peptide serves as a marker for diagnostically detecting inflammatory and/or excitation-inhibitory processes and diseases of the nervous system and as a basis for pharmaceutical compositions for treating diseases of the nervous system or for pharmaceutical compositions having an anaesthetic effect.
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Inventors:
BRINKMEIER HEINRICH (DE)
RUEDEL REINHARD (DE)
SCHNEIDER PETER (DE)
DANKWARDT ANDREA (DE)
RUEDEL REINHARD (DE)
SCHNEIDER PETER (DE)
DANKWARDT ANDREA (DE)
Application Number:
PCT/EP2001/001850
Publication Date:
April 11, 2002
Filing Date:
February 19, 2001
Export Citation:
Assignee:
SENSION BIOLOG DETEKTIONS UND (DE)
BRINKMEIER HEINRICH (DE)
RUEDEL REINHARD (DE)
SCHNEIDER PETER (DE)
DANKWARDT ANDREA (DE)
BRINKMEIER HEINRICH (DE)
RUEDEL REINHARD (DE)
SCHNEIDER PETER (DE)
DANKWARDT ANDREA (DE)
International Classes:
A61K31/7088; A61K38/00; A61K45/00; A61K48/00; A61P23/00; A61P25/00; A61P25/04; B01J20/281; G01N33/50; C07K1/16; C07K7/06; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12P21/02; C12P21/08; C12Q1/68; G01N30/88; G01N33/15; G01N33/53; G01N33/566; (IPC1-7): C12N15/11; C07K14/47; C07K7/06; C12N15/62; C07K16/18; G01N33/68; C12Q1/68; A61K38/04
Foreign References:
| FR2769226A1 | 1999-04-09 |
Other References:
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; AULKEMEYER, PETER ET AL: "The human endogenous local anesthetic-like factor (ELLF) is functionally neutralized by serum albumin", XP002181234, retrieved from STN Database accession no. 125:325143 CA
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; BRINKMEIER, HEINRICH (1) ET AL: "On the nature of endogenous antiexcitatory factors in the cerebrospinal fluid of patients with demyelinating neurological disease.", XP002181235, retrieved from STN Database accession no. 1996:64607
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; GRIFFIN, J. W. (1) ET AL: "Pathology of the motor-sensory axonal Guillain-Barre syndrome.", XP002181236, retrieved from STN Database accession no. 1996:127321
H BRINKMEIER ET AL.: "An endogenous pentapeptide acting as a sodium channel blocker in inflammatory autoimmune disorders of the central nervous system", NATURE MEDICINE., vol. 6, no. 7, July 2000 (2000-07-01), CO US, pages 808 - 811, XP002181233
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; WEBER, FRANK (1) ET AL: "A small sodium channel blocking factor in the cerebrospinal fluid is preferentially found in Guillain-Barre syndrome: A combined cell physiological and HPLC study.", XP002181237, retrieved from STN Database accession no. 2000:21112
H BRINKMEIER U. A.: "A pentapeptide from the human brain acting as a Na channel blocker", BIOPHYSICAL JOURNAL, 44TH ANNUAL MEETING OF THE BIOPHYSICAL SOCIETY, NEW ORLEANS, LOUISIANA, FEBRUARY 12-16, 2000, vol. 78, no. 1 part 2, January 2000 (2000-01-01), NEW YORK, US, US, pages 85a, XP001036662, ISSN: 0006-3495
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; BRINKMEIER, HEINRICH (1) ET AL: "On the nature of endogenous antiexcitatory factors in the cerebrospinal fluid of patients with demyelinating neurological disease.", XP002181235, retrieved from STN Database accession no. 1996:64607
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; GRIFFIN, J. W. (1) ET AL: "Pathology of the motor-sensory axonal Guillain-Barre syndrome.", XP002181236, retrieved from STN Database accession no. 1996:127321
H BRINKMEIER ET AL.: "An endogenous pentapeptide acting as a sodium channel blocker in inflammatory autoimmune disorders of the central nervous system", NATURE MEDICINE., vol. 6, no. 7, July 2000 (2000-07-01), CO US, pages 808 - 811, XP002181233
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; WEBER, FRANK (1) ET AL: "A small sodium channel blocking factor in the cerebrospinal fluid is preferentially found in Guillain-Barre syndrome: A combined cell physiological and HPLC study.", XP002181237, retrieved from STN Database accession no. 2000:21112
H BRINKMEIER U. A.: "A pentapeptide from the human brain acting as a Na channel blocker", BIOPHYSICAL JOURNAL, 44TH ANNUAL MEETING OF THE BIOPHYSICAL SOCIETY, NEW ORLEANS, LOUISIANA, FEBRUARY 12-16, 2000, vol. 78, no. 1 part 2, January 2000 (2000-01-01), NEW YORK, US, US, pages 85a, XP001036662, ISSN: 0006-3495
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