Title:
PEPTIDES, NANOVESICLES, AND USES THEREOF FOR DRUG DELIVERY
Document Type and Number:
WIPO Patent Application WO/2022/219075
Kind Code:
A3
Abstract:
The present disclosure pertains to polypeptides (in particular, polypeptides comprising Eph receptor domain(s), i.e., Eph receptor-derived polypeptides), nanovesicles (e.g., extracellular vesicles (EVs) and hybridosomes) comprising such polypeptides. Said polypeptides can act as membrane bound protein scaffolds to which molecules of interest can be attached. The polypeptides and nanovesicles can be used in targeting, therapeutic and/or diagnostic applications. Also provided are nucleic acids and expression vectors encoding such polypeptides as well as cells expressing said polypeptides. Further provided are methods for producing nanovesicles comprising such polypeptides. Compositions comprising such polypeptides or nanovesicles as well as their uses are also described.
Inventors:
DE BEER JOEL (CH)
MAURER MONIQUE (CH)
MEIER NICOLAS (CH)
KUNALINGAM LAVANIYA (CH)
CLERICI MARCELLO (CH)
MAURER MONIQUE (CH)
MEIER NICOLAS (CH)
KUNALINGAM LAVANIYA (CH)
CLERICI MARCELLO (CH)
Application Number:
PCT/EP2022/059940
Publication Date:
November 24, 2022
Filing Date:
April 13, 2022
Export Citation:
Assignee:
ANJARIUM BIOSCIENCES AG (CH)
International Classes:
C07K14/715; A61K51/08; C07K16/00; C12N9/12
Domestic Patent References:
| WO2001072833A2 | 2001-10-04 | |||
| WO2018015535A1 | 2018-01-25 |
Other References:
TIMOTHY H. UNG ET AL: "Exosome proteomics reveals transcriptional regulator proteins with potential to mediate downstream pathways", CANCER SCIENCE, vol. 105, no. 11, 9 October 2014 (2014-10-09), JP, pages 1384 - 1392, XP055699059, ISSN: 1347-9032, DOI: 10.1111/cas.12534
JANES PETER W. ET AL: "Eph receptor function is modulated by heterooligomerization of A and B type Eph receptors", THE JOURNAL OF CELL BIOLOGY, vol. 195, no. 6, 12 December 2011 (2011-12-12), US, pages 1033 - 1045, XP055949440, ISSN: 0021-9525, DOI: 10.1083/jcb.201104037
JANES PETER W. ET AL: "Eph receptor function is modulated by heterooligomerization of A and B type Eph receptors", THE JOURNAL OF CELL BIOLOGY, vol. 195, no. 6, 12 December 2011 (2011-12-12), US, pages 1033 - 1045, XP055949440, ISSN: 0021-9525, DOI: 10.1083/jcb.201104037
Attorney, Agent or Firm:
JONES DAY (DE)
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