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Title:
PERIODONTAL LIGAMENT-PROTECTING AGENT
Document Type and Number:
WIPO Patent Application WO/2005/092327
Kind Code:
A1
Abstract:
It is intended to provide a periodontal ligament-protecting agent which prevents failures in the periodontal tissue (in particular, periodontal ligament) caused by Porphyromonas gingivalis, and an oral preparation, a food or a drink having effects of preventing and treating diseases relating to damage in periodontal ligament which contains this periodontal ligament-protecting agent. Namely, a periodontal ligament-protecting agent which is a proanthocyanidine having an effect of relieving toxicity of Porphyromonas gingivalis to periodontal ligament (preferably a proanthocyanidine originating in immature apple fruit or hop bract); and an oral preparation, a food or a drink containing this periodontal ligament-protecting agent as the active ingredient.

Inventors:
INABA HIROAKI (JP)
TAGASHIRA MOTOYUKI (JP)
KANDA TOMOMASA (JP)
AMANO ATSUO (JP)
Application Number:
PCT/JP2005/003166
Publication Date:
October 06, 2005
Filing Date:
February 25, 2005
Export Citation:
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Assignee:
ASAHI BREWERIES LTD (JP)
INABA HIROAKI (JP)
TAGASHIRA MOTOYUKI (JP)
KANDA TOMOMASA (JP)
AMANO ATSUO (JP)
International Classes:
A23L1/30; A61K8/34; A61K8/97; A61K31/05; A61K31/352; A61P1/02; A61Q11/00; A61Q17/00; C07D311/62; (IPC1-7): A61K31/352; A23L1/30; A61K7/16; A61P1/02; C07D311/62
Domestic Patent References:
WO2003099304A12003-12-04
WO1999044574A11999-09-10
WO1999044440A11999-09-10
WO2002078726A12002-10-10
WO2001032131A12001-05-10
Foreign References:
JP2001275604A2001-10-09
JPH0881380A1996-03-26
JPH08259453A1996-10-08
JPH09295944A1997-11-18
JPH07285876A1995-10-31
JPH08319433A1996-12-03
JPH0477424A1992-03-11
JP2003504402A2003-02-04
JP2002029953A2002-01-29
JPH11302142A1999-11-02
JP2002121133A2002-04-23
JPH11501918A1999-02-16
JP2004051513A2004-02-19
JP2003535111A2003-11-25
JPH0631208B21994-04-27
JP2001511153A2001-08-07
JP2003252745A2003-09-10
JPH08104628A1996-04-23
Other References:
SONG S-E. ET AL: "Inhibitory effect of procyanidin oligomer from elm cortex on the matrix metalloproteinases and proteases of periodontopathogens", JOURNAL OF PERIODONTAL RESEARCH, vol. 38, no. 3, June 2003 (2003-06-01), pages 282 - 289, XP002987940
See also references of EP 1728509A4
Attorney, Agent or Firm:
Funahashi, Eiko (Nishishinbashi 1-chome Minato-ku, Tokyo, JP)
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