Title:
PHARMACEUTICAL COMPOSITION COMPRISING PIM-ACTIVATED NKT CELLS, AND THERAPEUTIC USE THEREOF
Document Type and Number:
WIPO Patent Application WO2000063348
Kind Code:
A3
Abstract:
The invention concerns a pharmaceutical composition comprising at least a PIM-activated NKT cell and the use of at least one PIM and/or a PIM-activated NKT cell for treating a disease for which a granulomatous type of immune response is desired.
Inventors:
APOSTOLOV IRINA (FR)
GACHELIN GABRIEL (FR)
KOURILSKY PHILIPPE (FR)
TAKAHAMA YOUSUKE (JP)
GACHELIN GABRIEL (FR)
KOURILSKY PHILIPPE (FR)
TAKAHAMA YOUSUKE (JP)
Application Number:
PCT/FR2000/001029
Publication Date:
December 28, 2000
Filing Date:
April 19, 2000
Export Citation:
Assignee:
INST NAT SANTE RECH MED (FR)
PASTEUR INSTITUT (FR)
APOSTOLOV IRINA (FR)
GACHELIN GABRIEL (FR)
KOURILSKY PHILIPPE (FR)
TAKAHAMA YOUSUKE (JP)
PASTEUR INSTITUT (FR)
APOSTOLOV IRINA (FR)
GACHELIN GABRIEL (FR)
KOURILSKY PHILIPPE (FR)
TAKAHAMA YOUSUKE (JP)
International Classes:
C12N5/07; A61K31/7034; A61K35/14; A61K35/17; A61K35/74; A61P31/04; A61P35/00; C12N5/077; C12N5/0783; A61K35/12; C12R1/91; (IPC1-7): C12N5/06; C12N5/08; A61K35/16; A61P35/00
Other References:
APOSTOLOU I ET AL: "Murine natural killer T( NKT ) cells [correction of natural killer cells] contribute to the granulomatous reaction caused by mycobacterial cell walls [published erratum appears in Proc Natl Acad Sci U S A 1999 Jun 22;96(13):7610].", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1999 APR 27) 96 (9) 5141-6., XP002129923
KOBAYASHI E ET AL: "Enhancing effects of agelasphin - 11 on natural killer cell activities of normal and tumor-bearing mice.", BIOLOGICAL AND PHARMACEUTICAL BULLETIN, (1996 MAR) 19 (3) 350-3., XP002911484
DATABASE WPI Section Ch Week 199905, Derwent World Patents Index; Class B03, AN 1999-059632, XP002129924
STANKOVA J ET AL: "Fucose-activated killer (FAK) cells: anomalous killers with augmented cytotoxic activity.", JOURNAL OF IMMUNOLOGY, (1985 DEC) 135 (6) 3719-28., XP002129922
KOBAYASHI E ET AL: "Enhancing effects of agelasphin - 11 on natural killer cell activities of normal and tumor-bearing mice.", BIOLOGICAL AND PHARMACEUTICAL BULLETIN, (1996 MAR) 19 (3) 350-3., XP002911484
DATABASE WPI Section Ch Week 199905, Derwent World Patents Index; Class B03, AN 1999-059632, XP002129924
STANKOVA J ET AL: "Fucose-activated killer (FAK) cells: anomalous killers with augmented cytotoxic activity.", JOURNAL OF IMMUNOLOGY, (1985 DEC) 135 (6) 3719-28., XP002129922
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