Title:
PHARMACEUTICAL COMPOSITION CONTAINING 27-HYDROXYCHOLESTEROL FOR PREVENTING OR TREATING MYELOID LEUKEMIA
Document Type and Number:
WIPO Patent Application WO/2023/068566
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition, containing 27-hydroxycholesterol, for preventing or treating myeloid leukemia, and more specifically, to a pharmaceutical composition which suppresses the proliferation of hematopoietic stem cells by increasing the active oxygen of the hematopoietic stem cells and activating a cascade of endoplasmic reticulum stress, and promotes the apoptosis of blood cancer cells by activating the IRE1a, eIF2a, and CHOP signaling pathways which are important for the apoptosis of blood cancer cells.
Inventors:
LEE DONGJUN (KR)
WOO SOO YEON (KR)
WOO SOO YEON (KR)
Application Number:
PCT/KR2022/013934
Publication Date:
April 27, 2023
Filing Date:
September 19, 2022
Export Citation:
Assignee:
NAT UNIV PUSAN IND UNIV COOP FOUND (KR)
International Classes:
A61K31/575; A23K20/168; A23L33/10; A61K8/63; A61P35/02; A61Q19/00
Domestic Patent References:
| WO2020214993A1 | 2020-10-22 |
Foreign References:
| KR20190018486A | 2019-02-22 |
Other References:
OGURO HIDEYUKI, DE LUCA, TONI, BIRBRAIR ALEXANDER, OGURO HIDEYUKI: "The Roles of Cholesterol and Its Metabolites in Normal and Malignant Hematopoiesis", FRONTIERS IN ENDOCRINOLOGY, vol. 10, 1 January 2019 (2019-01-01), pages 204, XP093058452, DOI: 10.3389/fendo.2019.00204
KUMAR RUPALI SANI; GOYAL NEENA: "Estrogens as regulator of hematopoietic stem cell, immune cells and bone biology", LIFE SCIENCE, PERGAMON PRESS, OXFORD, GB, vol. 269, 18 January 2021 (2021-01-18), GB , XP086493005, ISSN: 0024-3205, DOI: 10.1016/j.lfs.2021.119091
PEETERS, S.D.P.W.M. VAN DER KOLK, D.M. DE HAAN, G. BYSTRYKH, L. KUIPERS, F. DE VRIES, E.G.E. VELLENGA, E.: "Selective expression of cholesterol metabolism genes in normal CD34^+CD38^- cells with a heterogeneous expression pattern in AML cells", EXPERIMENTAL HEMATOLOGY, ELSEVIER INC., US, vol. 34, no. 5, 1 May 2006 (2006-05-01), US , pages 622 - 630, XP005413486, ISSN: 0301-472X, DOI: 10.1016/j.exphem.2006.01.020
KUMAR RUPALI SANI; GOYAL NEENA: "Estrogens as regulator of hematopoietic stem cell, immune cells and bone biology", LIFE SCIENCE, PERGAMON PRESS, OXFORD, GB, vol. 269, 18 January 2021 (2021-01-18), GB , XP086493005, ISSN: 0024-3205, DOI: 10.1016/j.lfs.2021.119091
PEETERS, S.D.P.W.M. VAN DER KOLK, D.M. DE HAAN, G. BYSTRYKH, L. KUIPERS, F. DE VRIES, E.G.E. VELLENGA, E.: "Selective expression of cholesterol metabolism genes in normal CD34^+CD38^- cells with a heterogeneous expression pattern in AML cells", EXPERIMENTAL HEMATOLOGY, ELSEVIER INC., US, vol. 34, no. 5, 1 May 2006 (2006-05-01), US , pages 622 - 630, XP005413486, ISSN: 0301-472X, DOI: 10.1016/j.exphem.2006.01.020
Attorney, Agent or Firm:
JUNGJIN IP LAW FIRM (KR)
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