Title:
PHARMACEUTICAL COMPOSITION CONTAINING NITROXOLINE PRODRUG, AND PREPARATION METHOD AND APPLICATION THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/238978
Kind Code:
A1
Abstract:
A pharmaceutical composition containing a nitroxoline prodrug, and a preparation method and an application therefor. The pharmaceutical composition comprises the following ingredients in parts by weight: 100 parts of active pharmaceutical ingredient, 22.5-320 parts of filler, 0-40 parts of disintegrant, 0-95 parts of binding agent, and 2-30 parts of lubricant; relative to each 100 parts by weight of active pharmaceutical ingredient, the total content of the filler, the disintegrant, and the binding agent is 54-345 parts by weight; the active pharmaceutical ingredient is (S)-(5-nitroxoline-8-yloxy)methyl 1-isopropylpyrrolidine-2-carboxylate. The pharmaceutical composition has good stability, dissolution properties, and pharmacokinetic characteristics.
Inventors:
CHEN JIE (CN)
SHEN SHUAI (CN)
WU YOUBIN (CN)
LIU JIANGHUA (CN)
GUO YUSHEN (CN)
SHEN SHUAI (CN)
WU YOUBIN (CN)
LIU JIANGHUA (CN)
GUO YUSHEN (CN)
Application Number:
PCT/CN2021/096037
Publication Date:
December 02, 2021
Filing Date:
May 26, 2021
Export Citation:
Assignee:
JIANGSU YAHONG MEDITECH CO LTD (CN)
SHANGHAI YAHONG MEDITECH CO LTD (CN)
SHANGHAI YAHONG MEDITECH CO LTD (CN)
International Classes:
A61K31/4709; A61K9/14; A61K9/16; A61K9/20; A61K9/28; A61K9/48; A61P13/02; A61P31/00; A61P35/00
Domestic Patent References:
| WO2020063824A1 | 2020-04-02 |
Foreign References:
| CN111514142A | 2020-08-11 |
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
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