Title:
PHARMACEUTICAL COMPOSITION FOR TREATMENT OR PREVENTION OF STRESS-RELATED DISORDERS
Document Type and Number:
WIPO Patent Application WO/2022/181763
Kind Code:
A1
Abstract:
The present invention provides a pharmaceutical composition for the treatment or prevention of stress-related disorders, stress-induced anxiety disorders, or stress-related disorders or anxiety disorders associated with depression that includes a selective δ-opioid receptor agonist as an active ingredient, the selective δ-opioid receptor agonist preferably also having a μ-opioid receptor antagonist action and a κ-opioid receptor antagonist action.
Inventors:
SAITOH AKIYOSHI (JP)
YAMADA DAISUKE (JP)
NAKATA ERIKO (JP)
YAMADA DAISUKE (JP)
NAKATA ERIKO (JP)
Application Number:
PCT/JP2022/007866
Publication Date:
September 01, 2022
Filing Date:
February 25, 2022
Export Citation:
Assignee:
UNIV TOKYO SCIENCE FOUND (JP)
NIPPON CHEMIPHAR CO (JP)
NIPPON CHEMIPHAR CO (JP)
International Classes:
A61K45/00; A61K31/439; A61K31/444; A61K31/4725; A61K31/497; A61K31/501; A61K31/506; A61P25/00; A61P25/18; A61P25/22; A61P25/24; A61P43/00
Domestic Patent References:
| WO2018052114A1 | 2018-03-22 | |||
| WO2018052114A1 | 2018-03-22 | |||
| WO2013035833A1 | 2013-03-14 |
Foreign References:
| JP2016095299A | 2016-05-26 | |||
| JP2021030974A | 2021-03-01 | |||
| JP2021117338A | 2021-08-10 |
Other References:
SUGIYAMA AZUSA, YAMADA MISA, FURUIE HIROKI, GOTOH LEO, SAITOH AKIYOSHI, NAGASE HIROSHI, OKA JUN-ICHIRO, YAMADA MITSUHIKO: "Systemic administration of a delta opioid receptor agonist, KNT-127, facilitates extinction learning of fear memory in rats", JOURNAL OF PHARMACOLOGICAL SCIENCES, JAPANESE PHARMACOLOGICAL SOCIETY , TOKYO, JP, vol. 139, no. 3, 1 March 2019 (2019-03-01), JP , pages 174 - 179, XP055961096, ISSN: 1347-8613, DOI: 10.1016/j.jphs.2019.01.002
YAMADA DAISUKE; YANAGISAWA SHOKO; YOSHIZAWA KAZUMI; YANAGITA SHINYA; OKA JUN-ICHIRO; NAGASE HIROSHI; SAITOH AKIYOSHI: "Selective agonists of the δ-opioid receptor, KNT-127 and SNC80, act differentially on extinction learning of contextual fear memory in mice", NEUROPHARMACOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 160, 22 September 2019 (2019-09-22), AMSTERDAM, NL, XP085891229, ISSN: 0028-3908, DOI: 10.1016/j.neuropharm.2019.107792
WATANABE YOSHIKAZU; HAYASHIDA KOHEI; SAITO DAISUKE; TAKAHASHI TOSHIHIRO; SAKAI JUNICHI; NAKATA ERIKO; KANDA TAKASHI; IWAI TAKASHI;: "Design and synthesis of novel δ opioid receptor agonists with an azatricyclodecane skeleton for improving blood-brain barrier penetration", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 27, no. 15, 26 May 2017 (2017-05-26), Amsterdam NL , pages 3495 - 3498, XP085117770, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2017.05.072
NAGASE HIROSHI; SAITOH AKIYOSHI: "Research and development of κ opioid receptor agonists and δ opioid receptor agonists", PHARMACOLOGY & THERAPEUTICS, ELSEVIER., GB, vol. 205, 22 October 2019 (2019-10-22), GB , XP085984089, ISSN: 0163-7258, DOI: 10.1016/j.pharmthera.2019.107427
NAKATA, ERIKO; SAITO AKINOBU, HIROSE MASARO; NAKAJIMA SATOSHI; UKEZONO MASATOSHI; GOTO REO; YAMADA MITSUHIKO; FUJII HIDEAKI; NAGAS: "Pharmacological action of the novel opioid δ receptor agonist NC-2800", ANALGESICS/OPIOID PEPTIDE SYMPOSIUM PROGRAM/ABSTRACTS; SEPTEMBER 8TH TO 9TH, 2017, vol. 37, 1 January 2017 (2017-01-01) - 9 September 2017 (2017-09-09), pages 19, XP009539379
EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 276, 1995, pages 131 - 135
EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 322, 1997, pages 27 - 30
JOURNAL OF PHARMACOLOGICAL SCIENCES, vol. 139, no. 3, 2019, pages 174 - 179
JOURNAL OF NEUROSCIENCE, vol. 2, no. 27, 2012, pages 9335 - 9343
DAVIES, BMORRIS T, PHYSIOLOGICAL PARAMETERS IN LABORATORY ANIMALS AND HUMANS, PHARM. RES, vol. 10, no. 7, 1993, pages 1093 - 1095
YAMADA DAISUKE; YANAGISAWA SHOKO; YOSHIZAWA KAZUMI; YANAGITA SHINYA; OKA JUN-ICHIRO; NAGASE HIROSHI; SAITOH AKIYOSHI: "Selective agonists of the δ-opioid receptor, KNT-127 and SNC80, act differentially on extinction learning of contextual fear memory in mice", NEUROPHARMACOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 160, 22 September 2019 (2019-09-22), AMSTERDAM, NL, XP085891229, ISSN: 0028-3908, DOI: 10.1016/j.neuropharm.2019.107792
WATANABE YOSHIKAZU; HAYASHIDA KOHEI; SAITO DAISUKE; TAKAHASHI TOSHIHIRO; SAKAI JUNICHI; NAKATA ERIKO; KANDA TAKASHI; IWAI TAKASHI;: "Design and synthesis of novel δ opioid receptor agonists with an azatricyclodecane skeleton for improving blood-brain barrier penetration", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 27, no. 15, 26 May 2017 (2017-05-26), Amsterdam NL , pages 3495 - 3498, XP085117770, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2017.05.072
NAGASE HIROSHI; SAITOH AKIYOSHI: "Research and development of κ opioid receptor agonists and δ opioid receptor agonists", PHARMACOLOGY & THERAPEUTICS, ELSEVIER., GB, vol. 205, 22 October 2019 (2019-10-22), GB , XP085984089, ISSN: 0163-7258, DOI: 10.1016/j.pharmthera.2019.107427
NAKATA, ERIKO; SAITO AKINOBU, HIROSE MASARO; NAKAJIMA SATOSHI; UKEZONO MASATOSHI; GOTO REO; YAMADA MITSUHIKO; FUJII HIDEAKI; NAGAS: "Pharmacological action of the novel opioid δ receptor agonist NC-2800", ANALGESICS/OPIOID PEPTIDE SYMPOSIUM PROGRAM/ABSTRACTS; SEPTEMBER 8TH TO 9TH, 2017, vol. 37, 1 January 2017 (2017-01-01) - 9 September 2017 (2017-09-09), pages 19, XP009539379
EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 276, 1995, pages 131 - 135
EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 322, 1997, pages 27 - 30
JOURNAL OF PHARMACOLOGICAL SCIENCES, vol. 139, no. 3, 2019, pages 174 - 179
JOURNAL OF NEUROSCIENCE, vol. 2, no. 27, 2012, pages 9335 - 9343
DAVIES, BMORRIS T, PHYSIOLOGICAL PARAMETERS IN LABORATORY ANIMALS AND HUMANS, PHARM. RES, vol. 10, no. 7, 1993, pages 1093 - 1095
Attorney, Agent or Firm:
TAZAKI Akira et al. (JP)
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