Title:
PHARMACEUTICALS FOR DEPRESSING AUTOIMMUNE DISORDERS BY IDIOTYPE BINDING FRAGMENTS OF ANTI-IDIOTYPIC ANTIBODIES
Document Type and Number:
WIPO Patent Application WO/2001/087331
Kind Code:
A1
Abstract:
The invention relates to medicine, biotechnology, immunopharmacology and consists in correcting the condition of a patient affected by an autoimmune disease. In order to inhibit an autoimmune process, patients are cured by a specific desensitizing therapy using pharmaceuticals containing idiotype binding fragments of anti-idiotypic antibodies representing steric (immunochemical) analogs of target antigens which are applied regularly in small doses to the mucous tunic of a patient, for example in the form of applications or as a component of a rectal or vaginal suppository. The efficiency of correction is evaluated by means of an enzyme-linked immunosorbent assay consisting in adsorbing immunochemical analogs of an antigen (for instance, the anti-idiotypic antibodies against the given antigen or Fab¿2?- fragments thereof) on a solid, followed by defining an immune reactivation of a serum antibody thereto.
Inventors:
MOROZOV SERGEY GEORGIEVICH (RU)
POLETAEV ALEKSANDR BORISOVICH (RU)
POLETAEV ALEKSANDR BORISOVICH (RU)
Application Number:
PCT/RU2001/000033
Publication Date:
November 22, 2001
Filing Date:
January 29, 2001
Export Citation:
Assignee:
MOROZOV SERGEY GEORGIEVICH (RU)
POLETAEV ALEKSANDR BORISOVICH (RU)
POLETAEV ALEKSANDR BORISOVICH (RU)
International Classes:
A61P37/06; C07K16/42; (IPC1-7): A61K39/00; A61K39/395; A61P37/06
Foreign References:
| RU96109830A | ||||
| US4232004A | 1980-11-04 |
Other References:
A.B. POLETAEV ET AL.: "Primenenie antiidiopticheskikh antitel dlya korrektsii autoimmunnykh reaktsy k belku mozga-s-100", BJULLETEN EXPERIMENTALNOI BIOLOGII I MEDITSINY, 1996, MOSCOW, MEDITSINA, pages 508 - 511
AL-SABBAGH ET AL.: "Antigen-driven peripheral immune tolerance: suppression of experimental autoimmune encephalomyelitis and collagen-induced arthritis by aerosol administration of myelin basic protein or type II collagen", CELL IMMUNOL., vol. 171, no. 1, 10 June 1996 (1996-06-10), pages 111 - 119
WEINER H.L.: "Oral tolerance for the treatment of autoimmune diseases", ANNU. REV. MED., vol. 48, 1997, pages 341 - 351
DANIELLE A.W. WOLVERS ET AL.: "Intranasally induced immunological tolerance is determined by the draining lymph nodes: studies with OVA and human cartilage gp-39", THE JOURNAL OF IMMUNOLOGY, vol. 163, no. 4, 1994, pages 1 - 12
BECKER M.I. ET AL.: "An alternative ELISA for T4 determination based on idiotype anti-idiotype interaction and a latex method for anti-idiotype monoclonal antibody selection", J. IMMUNOL. METHODS, vol. 192, no. 1-2, 10 June 1996 (1996-06-10), pages 73 - 85
AL-SABBAGH ET AL.: "Antigen-driven peripheral immune tolerance: suppression of experimental autoimmune encephalomyelitis and collagen-induced arthritis by aerosol administration of myelin basic protein or type II collagen", CELL IMMUNOL., vol. 171, no. 1, 10 June 1996 (1996-06-10), pages 111 - 119
WEINER H.L.: "Oral tolerance for the treatment of autoimmune diseases", ANNU. REV. MED., vol. 48, 1997, pages 341 - 351
DANIELLE A.W. WOLVERS ET AL.: "Intranasally induced immunological tolerance is determined by the draining lymph nodes: studies with OVA and human cartilage gp-39", THE JOURNAL OF IMMUNOLOGY, vol. 163, no. 4, 1994, pages 1 - 12
BECKER M.I. ET AL.: "An alternative ELISA for T4 determination based on idiotype anti-idiotype interaction and a latex method for anti-idiotype monoclonal antibody selection", J. IMMUNOL. METHODS, vol. 192, no. 1-2, 10 June 1996 (1996-06-10), pages 73 - 85
Attorney, Agent or Firm:
Morozov, Sergey Georgievich (43-19 Moscow, RU)
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