Title:
PHARMACEUTICALS FOR MODULATING HORMONE RESPONSIVENESS
Document Type and Number:
WIPO Patent Application WO1999005172
Kind Code:
A3
Abstract:
This invention relates to isolated and purified proteins, such as calreticulin and mimetics and inhibitors of calreticulin, for a novel use of modulating hormone responsiveness. These proteins are useful in gene therapy and in manufacturing pharmaceuticals for treating a variety of diseases, including cancer, osteoporosis and chronic inflammatory disease. The proteins include or bind to an amino acid sequence [SEQ ID NO:1] KXFFX<1>R, wherein X is either G, A or V and X<1> is either K or R. This sequence is present in the DNA-binding domain, and is critical for the DNA binding activity, of a variety of hormone receptors, including glucocorticoid receptor, minerolcorticoid receptor, androgen receptor, progesterone receptor, estrogen receptor, retinoic acid receptor, thyroid hormone receptor and vitamin D receptor. Proteins which bind to this sequence may inhibit hormone receptor induced gene transcription. Proteins which include this sequence may promote hormone receptor induced gene transcription. The invention includes isolated DNA molecules for these proteins, methods of treating diseases using these proteins, synthetic peptides or their mimetics.
Inventors:
DEDHAR SHOUKAT (CA)
DOERSEN CLAUS-JENS WALTER (US)
MAZUR ADAM WEISLAW (US)
DOERSEN CLAUS-JENS WALTER (US)
MAZUR ADAM WEISLAW (US)
Application Number:
PCT/CA1998/000715
Publication Date:
April 15, 1999
Filing Date:
July 24, 1998
Export Citation:
Assignee:
DEDHAR SHOUKAT (CA)
DOERSEN CLAUS JENS WALTER (US)
MAZUR ADAM WEISLAW (US)
DOERSEN CLAUS JENS WALTER (US)
MAZUR ADAM WEISLAW (US)
International Classes:
C07K7/06; C07K7/08; C07K14/47; (IPC1-7): C07K14/47; A61K38/08; A61K38/17; C07K7/06; C07K7/08
Domestic Patent References:
| WO1996023001A1 | 1996-08-01 | |||
| WO1993014098A1 | 1993-07-22 |
Foreign References:
| CA2140814A1 | 1996-07-24 |
Other References:
COPPOLINO M G ET AL: "CALRETICULIN IS ESSENTIAL FOR INTEGRIN-MEDIATED CALCIUM SIGNALLING AND CELL ADHESION", NATURE, vol. 386, 24 April 1997 (1997-04-24), pages 843 - 847, XP002072201
Y. CHOI ET AL.: "Tissue-specific and developmental regulation of a gene encoding a low-molecular weight sulfur-rich protein in soybean seeds", MOL. GEN. GENET, vol. 246, 1995, pages 266 - 268, XP002092536
Y. CHOI ET AL.: "Tissue-specific and developmental regulation of a gene encoding a low-molecular weight sulfur-rich protein in soybean seeds", MOL. GEN. GENET, vol. 246, 1995, pages 266 - 268, XP002092536
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