Title:
PHENYL SULFAMATE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2001/002349
Kind Code:
A1
Abstract:
Phenyl sulfamate derivatives of general formula (I) or salts thereof, exhibiting an excellent steroid sulfatase inhibitory activity and being therefore effective in the prevention or treatment of diseases related to steroids including estrogen, e.g., mammary carcinoma, carcinoma of uterine body, endometrial hyperplasia, sterility, endometriosis, adenomyosis of uterus, autoimmune diseases, dementia, Alzheimer's disease and so on, wherein R?1¿ and R?2¿ are each independently hydrogen or lower alkyl; R?3¿ is hydrogen, halogeno, lower alkyl, -OSO¿2?NR?1¿R?2¿, lower alkanoylamino, nitro, or cyano; and A is substituted or unsubstituted phenyl, -X-NR?4¿R?5¿, or the like.
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Inventors:
KOIZUMI NAOYUKI (JP)
OKADA MAKOTO (JP)
IWASHITA SHIGEKI (JP)
TAKEGAWA SHIGEHIRO (JP)
NAKAGAWA TAKAYOSHI (JP)
TAKAHASHI HIROO (JP)
FUJII TOMOHITO (JP)
OKADA MAKOTO (JP)
IWASHITA SHIGEKI (JP)
TAKEGAWA SHIGEHIRO (JP)
NAKAGAWA TAKAYOSHI (JP)
TAKAHASHI HIROO (JP)
FUJII TOMOHITO (JP)
Application Number:
PCT/JP2000/004427
Publication Date:
January 11, 2001
Filing Date:
July 04, 2000
Export Citation:
Assignee:
TEIKOKU HORMONE MFG CO LTD (JP)
KOIZUMI NAOYUKI (JP)
OKADA MAKOTO (JP)
IWASHITA SHIGEKI (JP)
TAKEGAWA SHIGEHIRO (JP)
NAKAGAWA TAKAYOSHI (JP)
TAKAHASHI HIROO (JP)
FUJII TOMOHITO (JP)
KOIZUMI NAOYUKI (JP)
OKADA MAKOTO (JP)
IWASHITA SHIGEKI (JP)
TAKEGAWA SHIGEHIRO (JP)
NAKAGAWA TAKAYOSHI (JP)
TAKAHASHI HIROO (JP)
FUJII TOMOHITO (JP)
International Classes:
A61K31/00; A61K31/18; A61K31/357; A61K31/36; A61K31/38; A61K31/381; A61K31/41; A61K31/4196; A61K31/42; A61K31/426; A61K31/495; A61K31/496; A61K31/4965; A61P15/00; A61P25/28; A61P35/00; A61P37/00; A61P37/06; A61P43/00; C07C307/02; C07D213/30; C07D213/74; C07D213/82; C07D239/42; C07D241/20; C07D249/08; C07D257/04; C07D261/10; C07D277/24; C07D277/26; C07D317/54; C07D333/20; C07D333/38; C07D521/00; (IPC1-7): C07C307/02; C07D213/30; C07D241/20; C07D249/08; C07D257/04; C07D261/10; C07D277/26; C07D317/54; C07D333/20; C07D333/38; A61K31/18; A61K31/36; A61K31/38; A61K31/41; A61K31/42; A61K31/426; A61K31/495; A61P15/00; A61P25/28; A61P35/00; A61P37/06; A61P43/00
Domestic Patent References:
| WO1997032872A1 | 1997-09-12 |
Foreign References:
| US5192785A | 1993-03-09 |
Other References:
A. PUROHIT ET AL.: "Recent advances in the development of steroid sulfatase inhibitors", J. STEROID BIOCHEM. MOL. BIOL., vol. 69, no. 1-6, 1999, pages 227 - 238, XP002932557
APARNA KOLLI ET AL.: "Development of (p-O-sulfamoyl)-N-alkanoyl-phenylalkyl amines as non-steroidal estrone sulfatase inhibitors", J. STEROID BIOCHEM. MOL. BIOL., vol. 68, no. 1-2, 1999, pages 31 - 40, XP002932558
GUO-HUA CHU ET AL.: "Synthesis and sulfatase inhibitory activities of (E)- and (Z)-4-hydroxytamoxifen sulfamates", BIOORG. MED. CHEM. LETT., vol. 9, no. 2, 1999, pages 141 - 144, XP002932559
APARNA KOLLI ET AL.: "Development of (p-O-sulfamoyl)-N-alkanoyl-phenylalkyl amines as non-steroidal estrone sulfatase inhibitors", J. STEROID BIOCHEM. MOL. BIOL., vol. 68, no. 1-2, 1999, pages 31 - 40, XP002932558
GUO-HUA CHU ET AL.: "Synthesis and sulfatase inhibitory activities of (E)- and (Z)-4-hydroxytamoxifen sulfamates", BIOORG. MED. CHEM. LETT., vol. 9, no. 2, 1999, pages 141 - 144, XP002932559
Attorney, Agent or Firm:
Odajima, Heikichi (Nippon Jitensha Building 9-15, Akasaka 1-chom, Minato-ku Tokyo, JP)
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