Title:
PHENYLALANINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2005/068415
Kind Code:
A1
Abstract:
Disclosed is a phenylalanine derivative having excellent VLA-4 inhibitory activity which is represented by the following general formula (1) or a salt thereof. (1) (In the formula, R1 represents an aromatic hydrocarbon group having 6-10 carbon atoms or the like; Z represents a phenyl group or the like; R2 represents a hydrogen atom or a lower alkyl group; n represents a number such as 0; and when n is 0, Y represents NOR3 (wherein R3 represents a methyl group or the like), CCl2 or the like.)
Inventors:
UDA JUNICHIRO (JP)
OKAMOTO YASUSHI (JP)
IWABUCHI TAKEYUKI (JP)
INOUE TSUTOMU (JP)
NAKANO HIROYUKI (JP)
ISHIKAWA TOMOHIKO (JP)
KAWASAKI NOBUHIDE (JP)
KATOH MASUMI (JP)
OKAMOTO YASUSHI (JP)
IWABUCHI TAKEYUKI (JP)
INOUE TSUTOMU (JP)
NAKANO HIROYUKI (JP)
ISHIKAWA TOMOHIKO (JP)
KAWASAKI NOBUHIDE (JP)
KATOH MASUMI (JP)
Application Number:
PCT/JP2005/000666
Publication Date:
July 28, 2005
Filing Date:
January 20, 2005
Export Citation:
Assignee:
FUJIYAKUHIN CO LTD (JP)
UDA JUNICHIRO (JP)
OKAMOTO YASUSHI (JP)
IWABUCHI TAKEYUKI (JP)
INOUE TSUTOMU (JP)
NAKANO HIROYUKI (JP)
ISHIKAWA TOMOHIKO (JP)
KAWASAKI NOBUHIDE (JP)
KATOH MASUMI (JP)
UDA JUNICHIRO (JP)
OKAMOTO YASUSHI (JP)
IWABUCHI TAKEYUKI (JP)
INOUE TSUTOMU (JP)
NAKANO HIROYUKI (JP)
ISHIKAWA TOMOHIKO (JP)
KAWASAKI NOBUHIDE (JP)
KATOH MASUMI (JP)
International Classes:
C07C233/31; C07C233/49; C07C233/50; C07C233/51; C07C251/38; C07C251/40; C07C251/42; C07C251/44; C07C251/48; C07C317/44; C07C323/59; C07C323/63; C07D209/20; C07D211/34; C07D213/56; C07D295/205; C07D307/54; C07D309/06; C07D317/60; C07D333/24; C07D335/02; C07D339/08; C07D409/12; (IPC1-7): C07C233/49; A61K31/198; A61K31/341; A61K31/351; A61K31/36; A61K31/381; A61K31/382; A61K31/385; A61K31/4409; A61K31/4433; A61K31/4436; A61K31/4439; A61K31/5375; A61P29/00; A61P43/00; C07C233/51; C07C251/34; C07C317/50; C07C323/59; C07C323/63; C07D209/04; C07D211/06; C07D213/53; C07D295/20; C07D309/06; C07D317/58; C07D333/22; C07D335/02; C07D339/08; C07D405/12; C07D409/12; C07D417/04
Other References:
CHEN L. ET AL: "N-Acyl phenylalanine analogues as potent small molecule VLA-4 antagonists", BIOORGANIC & MEDICAL CHEMISTRY, vol. 10, no. 8, April 2000 (2000-04-01), pages 725 - 727
Attorney, Agent or Firm:
The, Patent Corporate Body Aruga Patent Office (3-6 NIHONBASHININGYOCHO 1-CHOME CHUO-KU, Tokyo 13, JP)
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