PHOSPHODIESTERASE IV INHIBITOR CONTAINING PYRIDYLACRYLAMIDE DERIVATIVE

Title:

PHOSPHODIESTERASE IV INHIBITOR CONTAINING PYRIDYLACRYLAMIDE DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/2003/086396

Kind Code:

A1

Abstract:

A phosphodiesterase IV inhibitor which contains as an active ingredient either a pyridylacrylamide derivative represented by the following formula (I): (I) (wherein Ar¹ represents (un)substituted pyridyl; Ar² represents phenyl substituted by alkoxy, etc.; R¹ represents hydrogen, alkyl, or aryl; R² represents hydrogen, alkyl, cyano, or alkoxycarbonyl; R³ represents hydrogen or optionally substituted alkyl; X represents oxygen or sulfur; A and B are the same or different and each represents hydrogen, hydroxy, alkoxy, or alkylthio, or A and B both in cooperation represent oxo, thioxo, etc., provided that when A is hydroxy, then B may be 1-alkylimidazol-2-yl; and n is an integer of 1 to 3) or a pharmaceutically acceptable salt of the derivative.

Inventors:

HATTORI TOMOHISA (JP)
SASAKI TOSHINOBU (JP)
HASEGAWA YOSHIHIRO (JP)
OBATA TATSUHIRO (JP)

Application Number:

PCT/JP2003/004227

Publication Date:

October 23, 2003

Filing Date:

April 02, 2003

Export Citation:

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Assignee:

TSUMURA & CO (JP)
HATTORI TOMOHISA (JP)
SASAKI TOSHINOBU (JP)
HASEGAWA YOSHIHIRO (JP)
OBATA TATSUHIRO (JP)

International Classes:

A61P1/04; A61P11/06; A61P11/08; A61P17/00; A61P17/04; A61P19/02; A61P25/18; A61P25/24; A61P27/02; A61P27/16; A61P29/00; A61P31/04; A61P37/08; A61P43/00; C07D213/56; C07D213/57; C07D213/59; C07D213/61; C07D213/65; C07D213/80; C07D405/12; A61K31/4406; (IPC1-7): A61K31/4406; A61K31/443; A61K31/44; A61K31/4402; A61K31/4409; A61P1/04; A61P11/06; A61P11/08; A61P17/00; A61P19/02; A61P25/18; A61P25/24; A61P27/02; A61P27/16; A61P29/00; A61P31/04; A61P37/08; A61P43/00; A61P17/04

Domestic Patent References:

WO1999005109A1	1999-02-04
WO1998045268A1	1998-10-15
WO1993004035A1	1993-03-04

Foreign References:

EP0882714A1

1998-12-09

Attorney, Agent or Firm:

Hiraki, Yusuke (17-1 Toranomon 1-chom, Minato-ku Tokyo, JP)

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