Title:
PHOSPHOINOSITIDE 3-KINASE INHIBITORS FOR INHIBITING LEUKOCYTE ACCUMULATION
Document Type and Number:
WIPO Patent Application WO2006089106
Kind Code:
A3
Abstract:
The invention relates generally to phosphoinositide 3-kinases (PI3Ks) , and more particularly to methods of inhibiting leukocyte accumulation comprising selectively inhibiting phosphoinositide 3-kinase delta (PI3Kd) and phosphoinositide 3-kinase gamma (PI3K?) activities in endothelial cells. The disclosed methods may be used to treat individuals having an inflammatory condition where leukocytes are found to be accumulating at the site of insult or inflamed tissue. The inflammatory condition may be attributed to or associated with an underlying disorder not typically associated with inflammation, e.g. cancer, coronary vascular disease, etc.
Inventors:
DIACOVO THOMAS G (US)
HAYFLICK JOEL S (US)
PURI KAMAL D (US)
HAYFLICK JOEL S (US)
PURI KAMAL D (US)
Application Number:
PCT/US2006/005621
Publication Date:
December 07, 2006
Filing Date:
February 16, 2006
Export Citation:
Assignee:
ICOS CORP (US)
UNIV WASHINGTON (US)
DIACOVO THOMAS G (US)
HAYFLICK JOEL S (US)
PURI KAMAL D (US)
UNIV WASHINGTON (US)
DIACOVO THOMAS G (US)
HAYFLICK JOEL S (US)
PURI KAMAL D (US)
International Classes:
A61K31/41; A61K31/517; A61K31/52; A61P29/00
Domestic Patent References:
| WO2001081346A2 | 2001-11-01 | |||
| WO2003035075A1 | 2003-05-01 | |||
| WO2005120511A1 | 2005-12-22 | |||
| WO2005016349A1 | 2005-02-24 |
Foreign References:
| US20040259926A1 | 2004-12-23 |
Other References:
SADHU C ET AL: "Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 170, no. 5, 1 March 2003 (2003-03-01), pages 2647 - 2654, XP002327027, ISSN: 0022-1767
PURI KAMAL D ET AL: "The role of endothelial PI3K-gamma activity in neutrophil trafficking", BLOOD, vol. 106, no. 1, July 2005 (2005-07-01), pages 150 - 157,144, XP002395130, ISSN: 0006-4971
PURI KAMAL D ET AL: "The role of endothelial PI3K-gamma activity in neutrophil trafficking", BLOOD, vol. 106, no. 1, July 2005 (2005-07-01), pages 150 - 157,144, XP002395130, ISSN: 0006-4971
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