Title:
PHOTOMETRIC ANALYSIS DEVICE AND PHOTOMETRIC ANALYSIS METHOD USING WAVELENGTH CHARACTERISTIC OF LIGHT EMITTED FROM SINGLE ILLUMINANT PARTICLE
Document Type and Number:
WIPO Patent Application WO/2012/070414
Kind Code:
A1
Abstract:
The present invention relates to the technology for detecting and analyzing light emitted from illuminant particles, the technology being based on a scanning molecule counting method using light measurement by a confocal microscope or a multiphoton microscope. This technology is characterized by including: changing the optical path of an optical system in a microscope, thereby detecting the intensity of components at a plurality of wavelength bands of light emitted from a light detecting region while moving the position of the light detecting region of the optical system in a sample solution; independently detecting optical signals from each illuminant particle with the detected intensity of the components at the plurality of wavelength bands of light; and distinguishing the types of the illuminant particles on the basis of the intensity of the components at the plurality of wavelength bands of the detected optical signals from the illuminant particles.
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Inventors:
HANASHI TAKUYA (JP)
TANABE TETSUYA (JP)
YAMAGUCHI MITSUSHIRO (JP)
TANABE TETSUYA (JP)
YAMAGUCHI MITSUSHIRO (JP)
Application Number:
PCT/JP2011/076151
Publication Date:
May 31, 2012
Filing Date:
November 14, 2011
Export Citation:
Assignee:
OLYMPUS CORP (JP)
HANASHI TAKUYA (JP)
TANABE TETSUYA (JP)
YAMAGUCHI MITSUSHIRO (JP)
HANASHI TAKUYA (JP)
TANABE TETSUYA (JP)
YAMAGUCHI MITSUSHIRO (JP)
International Classes:
G01N21/64
Domestic Patent References:
| WO2010084719A1 | 2010-07-29 | |||
| WO2009117033A2 | 2009-09-24 | |||
| WO2011108371A1 | 2011-09-09 | |||
| WO2008080417A1 | 2008-07-10 |
Foreign References:
| JP2010190730A | 2010-09-02 | |||
| JP2008116440A | 2008-05-22 | |||
| JP2011002415A | 2011-01-06 | |||
| JP2005098876A | 2005-04-14 | |||
| JP2008292371A | 2008-12-04 | |||
| JP2009281831A | 2009-12-03 | |||
| JP4023523B2 | 2007-12-19 | |||
| JP2007020565A | 2007-02-01 | |||
| JP2008116440A | 2008-05-22 | |||
| JPH04337446A | 1992-11-25 | |||
| JP2010044714A | 2010-02-25 | |||
| JP2011053481W | 2011-02-18 |
Other References:
MASATAKA KANESHIRO, PROTEIN, NUCLEIC ACID, ENZYME, vol. 44, no. 9, 1999, pages 1431 - 1438
F.J.MEYER-ALMS: "Fluorescence Correlation Spectroscopy", 2000, SPRINGER, pages: 204 - 224
NORIKO KATO ET AL., GENE MEDICINE, vol. 6, no. 2, pages 271 - 277
P. KASK; K. PALO; D. ULLMANN; K. GALL, PNAS, vol. 96, 1999, pages 13756 - 13761
See also references of EP 2631631A4
F.J.MEYER-ALMS: "Fluorescence Correlation Spectroscopy", 2000, SPRINGER, pages: 204 - 224
NORIKO KATO ET AL., GENE MEDICINE, vol. 6, no. 2, pages 271 - 277
P. KASK; K. PALO; D. ULLMANN; K. GALL, PNAS, vol. 96, 1999, pages 13756 - 13761
See also references of EP 2631631A4
Attorney, Agent or Firm:
AKASHI, Masaki et al. (JP)
Masatake Akashi (JP)
Masatake Akashi (JP)
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Claims: