Title:
PIF PEPTIDES BIOLOGIC ACTIVITIES, SITE OF ACTION, AND THE ANTIBODY TO DETECT PIF
Document Type and Number:
WIPO Patent Application WO2005040196
Kind Code:
A3
Abstract:
A novel class of embryo derived peptides are described (Preimplantation factor) that were generated synthetically and were tested on peripheral blood immune cells and shown to block activated but not basal immunity, inhibiting cell proliferation and creating a TH2 type cytokine bias, in addition PIF enhance endometrial receptivity by increasing adhesion molecules expression. PIF biological activity appears to be exerted by specific binding to inducible receptors present on the several white cell lineages. PIF peptides, which are immune modulators therefore may have diagnostic and non toxic therapeutic applications in improving fertility, reducing pregnancy loss as well may be useful when administered for the treatment of autoimmune diseases and for prevention xenotransplants rejection. Further, polyclonal antibodies against PIF peptides were generated that serve for precise measurements of PIF in biological fluids. They document pregnancy presence and viability as well it helps for monitoring pregnancies at risk in humans as well as in farm and non farm animals, improving animal husbandry, where currently no specific pregnancy test exists. Also the PIF antibodies may have additional therapeutic properties for treatment of HIV, and malaria.
Inventors:
BARNEA EYTAN R (US)
Application Number:
PCT/US2004/035382
Publication Date:
August 17, 2006
Filing Date:
October 22, 2004
Export Citation:
Assignee:
BIOINCEPT LLC (US)
BARNEA EYTAN R (US)
BARNEA EYTAN R (US)
International Classes:
G01N33/00; G01N33/564; G01N33/68; C07K
Other References:
GONZALEZ ET AL.: "PREIMPLANTATION FACTORS (PIF) EMBRYO-DERIVED IMMUNOMODULATORY PEPTIDES: POSSIBLE IMPLICATIONS FOR MATERNAL RECOGNITION AND ALLOGRAFT TOLERANCE", AME.J. OF REPROD IMMUN., vol. 47, no. 6, 2002, XP003000084
ROUSSEV ET AL.: "Development and Validation of an assay for measuring preimplantation factor (PIF) of embryonal arigin", AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, vol. 35, 1996, pages 281 - 287, XP008067941
ROUSSEV ET AL.: "A novel bioassay for detection of preimplantation factor (PIF)", AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, vol. 33, 1995, pages 68 - 73, XP002966955
ROUSSEV ET AL.: "Development and Validation of an assay for measuring preimplantation factor (PIF) of embryonal arigin", AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, vol. 35, 1996, pages 281 - 287, XP008067941
ROUSSEV ET AL.: "A novel bioassay for detection of preimplantation factor (PIF)", AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, vol. 33, 1995, pages 68 - 73, XP002966955
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