Title:
PLANT BRANCHED-CHAIN AMINO ACID BIOSYNTHETIC ENZYMES
Document Type and Number:
WIPO Patent Application WO1999021880
Kind Code:
A3
Abstract:
This invention relates to an isolated nucleic acid fragment encoding a branched-chain biosynthetic enzyme. The invention also relates to the construction of a chimeric gene encoding all or a portion of the branched-chain biosynthetic enzyme, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the branched-chain biosynthetic enzyme in a transformed host cell.
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Inventors:
FALCO SAVERIO CARL (US)
CAHOON REBECCA E (US)
HITZ WILLIAM D (US)
KINNEY ANTHONY J (US)
RAFALSKI J ANTONI (US)
CAHOON REBECCA E (US)
HITZ WILLIAM D (US)
KINNEY ANTHONY J (US)
RAFALSKI J ANTONI (US)
Application Number:
PCT/US1998/022081
Publication Date:
November 25, 1999
Filing Date:
October 20, 1998
Export Citation:
Assignee:
DU PONT (US)
FALCO SAVERIO CARL (US)
CAHOON REBECCA E (US)
HITZ WILLIAM D (US)
KINNEY ANTHONY J (US)
RAFALSKI J ANTONI (US)
FALCO SAVERIO CARL (US)
CAHOON REBECCA E (US)
HITZ WILLIAM D (US)
KINNEY ANTHONY J (US)
RAFALSKI J ANTONI (US)
International Classes:
C12N9/10; C12N9/88; C12N15/82; (IPC1-7): C12N9/10; C12N15/54; C12N15/82; C12N5/14; A01H1/00
Domestic Patent References:
| WO1994008020A1 | 1994-04-14 |
Other References:
PIRRUNG M C ET AL: "MECHANISM AND STEREOCHEMISTRY OF ALPHABETA-DIHYDROXYACID DEHYDRATASE", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 113, 1 January 1991 (1991-01-01), pages 1020 - 1025, XP000196403
M. KANAMORI AND R.L. WIXOM: "Studies in Valine biosynthesis. V: Characteristics of the purified dyhydroxyacid dehydratase from spinach leaves", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 238, no. 3, 1963, pages 998 - 1005, XP002102471
D.H. FLINT AND M.H. EMPTAGE: "Dyhydroxy acid dehydratase from Spinach contains a [2Fe-2S] cluster", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 263, no. 8, 1988, pages 3558 - 3564, XP002102472
R.W. WALLSGROVE ET AL.,: "Biochemical characterisation of Nicotiana plumbaginifolia auxotrophs that require branched-chain amino acids", PLANT CELL REPORTS, vol. 3, 1986, pages 223 - 226, XP002102473
R.M. WALLSGROVE TE AL.,: "Biochemical characterisation of an auxotroph of Datura innoxia requiring isoleucine and valine", PLANT SCIENCE, vol. 43, 1986, pages 109 - 114, XP002102474
B.J. MAZUR ET AL.,: "Isolation and characterization of plant genes coding for acetolactate synthase, the target enzyme for two classes of herbicides", PLANT PHYSIOLOGY, vol. 85, 1987, pages 1110 - 1117, XP002102475
R. DUMAS ET AL.,: "ISOLATION, CHARACTERIZATION AND SEQUENCE ANALYSIS OF A FULL-LENGHT cDNA CLONE ENCODING ACETOHYDROXY ACID REDUCTOISOMERASE FROM SPINACH CHLOROPLASTS .", THE BIOCHEMICAL JOURNAL, vol. 277, no. 2, 1991, pages 469 - 475, XP002102476
J.A. VELASCO ET AL.,: "Cloning of the dihydroxydehydratse-encoding gene (ILV3) from Saccaromyces cerevisiae", GENE, vol. 137, no. 2, 1993, pages 179 - 185, XP002102477
J-J. GODON ET AL.,: "Branched-chain amino acid biosynthesis genes in Lactococcus lactis subsp. lactis", JOURNAL OF BACTERIOLOGY, vol. 174, no. 20, 1992, pages 6580 - 6589, XP002102479
R.P. LAWTHER ET AL.,: "The complete nucleotide sequence of the ilvGMEDA operon of Escherichia coli K-12", NUCLEIC ACID RESEARCH, vol. 15, no. 5, 1987, pages 2137 - 2155, XP002102478
M. KANAMORI AND R.L. WIXOM: "Studies in Valine biosynthesis. V: Characteristics of the purified dyhydroxyacid dehydratase from spinach leaves", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 238, no. 3, 1963, pages 998 - 1005, XP002102471
D.H. FLINT AND M.H. EMPTAGE: "Dyhydroxy acid dehydratase from Spinach contains a [2Fe-2S] cluster", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 263, no. 8, 1988, pages 3558 - 3564, XP002102472
R.W. WALLSGROVE ET AL.,: "Biochemical characterisation of Nicotiana plumbaginifolia auxotrophs that require branched-chain amino acids", PLANT CELL REPORTS, vol. 3, 1986, pages 223 - 226, XP002102473
R.M. WALLSGROVE TE AL.,: "Biochemical characterisation of an auxotroph of Datura innoxia requiring isoleucine and valine", PLANT SCIENCE, vol. 43, 1986, pages 109 - 114, XP002102474
B.J. MAZUR ET AL.,: "Isolation and characterization of plant genes coding for acetolactate synthase, the target enzyme for two classes of herbicides", PLANT PHYSIOLOGY, vol. 85, 1987, pages 1110 - 1117, XP002102475
R. DUMAS ET AL.,: "ISOLATION, CHARACTERIZATION AND SEQUENCE ANALYSIS OF A FULL-LENGHT cDNA CLONE ENCODING ACETOHYDROXY ACID REDUCTOISOMERASE FROM SPINACH CHLOROPLASTS .", THE BIOCHEMICAL JOURNAL, vol. 277, no. 2, 1991, pages 469 - 475, XP002102476
J.A. VELASCO ET AL.,: "Cloning of the dihydroxydehydratse-encoding gene (ILV3) from Saccaromyces cerevisiae", GENE, vol. 137, no. 2, 1993, pages 179 - 185, XP002102477
J-J. GODON ET AL.,: "Branched-chain amino acid biosynthesis genes in Lactococcus lactis subsp. lactis", JOURNAL OF BACTERIOLOGY, vol. 174, no. 20, 1992, pages 6580 - 6589, XP002102479
R.P. LAWTHER ET AL.,: "The complete nucleotide sequence of the ilvGMEDA operon of Escherichia coli K-12", NUCLEIC ACID RESEARCH, vol. 15, no. 5, 1987, pages 2137 - 2155, XP002102478
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