Title:
PLANT PRODUCTION OF IMMUNOGLOBULINS WITH REDUCED FUCOSYLATION
Document Type and Number:
WIPO Patent Application WO2004050838
Kind Code:
A3
Abstract:
This invention provides for the plant production of immunoglobulins, wherein at least a portion of the glycans attached to the immunoglobulins lack fucose. The invention also provides the constructs; plasmids; vectors; transformed plant cells, transformed plant calli, transformed plant tissues (e.g., leaves, seeds, tubers, etc.) and transformed whole plants used to produce such immunoglobulins; methods of producing the immunoglobulins; the immunoglobulins produced by the disclosed methods; and the use of such immunoglobulins.
Inventors:
BRIGGS KRISTEN (US)
GLANCY TODD (US)
HEIN MICH B (US)
HIATT ANDREW C (US)
KARNOUP ANTON S (US)
ANDERSON W H KERR (US)
PAREDDY DAYAKAR (US)
PETOLINO JOSEPH (US)
RUBIN-WILSON BETH (US)
TAYLOR DOUG (US)
ROBERTS JEAN L (US)
GLANCY TODD (US)
HEIN MICH B (US)
HIATT ANDREW C (US)
KARNOUP ANTON S (US)
ANDERSON W H KERR (US)
PAREDDY DAYAKAR (US)
PETOLINO JOSEPH (US)
RUBIN-WILSON BETH (US)
TAYLOR DOUG (US)
ROBERTS JEAN L (US)
Application Number:
PCT/US2003/037905
Publication Date:
August 03, 2006
Filing Date:
November 28, 2003
Export Citation:
Assignee:
DOW CHEMICAL CO (US)
DOW AGROSCIENCES LLC (US)
BRIGGS KRISTEN (US)
GLANCY TODD (US)
HEIN MICH B (US)
HIATT ANDREW C (US)
KARNOUP ANTON S (US)
ANDERSON W H KERR (US)
PAREDDY DAYAKAR (US)
PETOLINO JOSEPH (US)
RUBIN-WILSON BETH (US)
TAYLOR DOUG (US)
ROBERTS JEAN L (US)
DOW AGROSCIENCES LLC (US)
BRIGGS KRISTEN (US)
GLANCY TODD (US)
HEIN MICH B (US)
HIATT ANDREW C (US)
KARNOUP ANTON S (US)
ANDERSON W H KERR (US)
PAREDDY DAYAKAR (US)
PETOLINO JOSEPH (US)
RUBIN-WILSON BETH (US)
TAYLOR DOUG (US)
ROBERTS JEAN L (US)
International Classes:
C12N15/12; A01H1/00; C07K16/00; C07K16/08; C07K16/28; C12N15/82
Foreign References:
| US20020174453A1 | 2002-11-21 |
Other References:
BAKKER ET AL.: "Galactose-extended glycans of antibodies produced by transgenic plants", PNAS, vol. 98, no. 5, 27 February 2001 (2001-02-27), pages 2899 - 2904, XP002226729
ELBERS ET AL.: "Influence of Growth Conditions and Development Stage on N-Glycan Heterogeneity of Transgenic Immunoglobulin G and Endogenouse Proteins in Tobacco Leaves", PLANT PHYSIOLOGY, vol. 126, July 2001 (2001-07-01), pages 1314 - 1322, XP002263654
MADISON M. A. ET AL.: "Altered xyloglucans of Arabidopsis thalianamutants bind normally to cellulose in vivo and in vitro", POSTER FROM PLANT BIOLOGY, vol. 2001, no. ABSTR. #527, 21 July 2001 (2001-07-21) - 27 July 2001 (2001-07-27), XP009101874
"Molecular Farming of plants and animals for human and veterinary medicine", 2002, KLUWER ACADEMIC PUBLISHERS, article ERICKSON ET AL.: "Control of the N-glycosulation of therapeutic glycoproteins produced in transgenic plants: a new challenge for glycobiologists.", XP001538372
ERNST ET AL.: "Carbohydrates in Chemistry and Biology, Part II", vol. 4, 2000, article WARNER T. G.: "Metabolic engineering glycosylation: biotechnology's challenge to the glycobiologist in the next millenium", XP009101875
FUJIYAMA ET AL.: "In Vivo Conversion of a Glycan to Human Compatible Type by Transformed Tobacco Cells", BIOCHEMICAL AND NIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 289, 2001, pages 553 - 557, XP002229096
FISCHER ET AL.: "Molecular Farming of Pharmaceutical Proteins", TRANSGENIC RESEARCH, vol. 9, 2000, pages 279 - 299, XP002308459
See also references of EP 1606385A4
ELBERS ET AL.: "Influence of Growth Conditions and Development Stage on N-Glycan Heterogeneity of Transgenic Immunoglobulin G and Endogenouse Proteins in Tobacco Leaves", PLANT PHYSIOLOGY, vol. 126, July 2001 (2001-07-01), pages 1314 - 1322, XP002263654
MADISON M. A. ET AL.: "Altered xyloglucans of Arabidopsis thalianamutants bind normally to cellulose in vivo and in vitro", POSTER FROM PLANT BIOLOGY, vol. 2001, no. ABSTR. #527, 21 July 2001 (2001-07-21) - 27 July 2001 (2001-07-27), XP009101874
"Molecular Farming of plants and animals for human and veterinary medicine", 2002, KLUWER ACADEMIC PUBLISHERS, article ERICKSON ET AL.: "Control of the N-glycosulation of therapeutic glycoproteins produced in transgenic plants: a new challenge for glycobiologists.", XP001538372
ERNST ET AL.: "Carbohydrates in Chemistry and Biology, Part II", vol. 4, 2000, article WARNER T. G.: "Metabolic engineering glycosylation: biotechnology's challenge to the glycobiologist in the next millenium", XP009101875
FUJIYAMA ET AL.: "In Vivo Conversion of a Glycan to Human Compatible Type by Transformed Tobacco Cells", BIOCHEMICAL AND NIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 289, 2001, pages 553 - 557, XP002229096
FISCHER ET AL.: "Molecular Farming of Pharmaceutical Proteins", TRANSGENIC RESEARCH, vol. 9, 2000, pages 279 - 299, XP002308459
See also references of EP 1606385A4
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