Title:
POLYAMINE COMPOUNDS AND COMPOSITIONS FOR USE IN CONJUNCTION WITH CANCER THERAPY
Document Type and Number:
WIPO Patent Application WO2003066572
Kind Code:
B1
Abstract:
The invention provides novel polyamine compounds and pharmaceutical compositions for administration in conjunction with cancer chemotherapy or radiation therapy. The compounds are administered locally to provide protection against the adverse side-effects of chemotherapy or radiation therapy, such as alopecia, mucositis and dermatitis. Pharmaceutical preparations comprising one or more chemoprotective polyamines formulated for topical or local delivery to epithelial or mucosal cells are disclosed. Methods of administering the pharmaceutical preparations are also disclosed.
Inventors:
FAHL WILLIAM E (US)
COPP RICHARD R (US)
OCHSNER CYNTHIA E (US)
PEEBLES DANIEL D (US)
FAHL KATHLEEN L (US)
COPP RICHARD R (US)
OCHSNER CYNTHIA E (US)
PEEBLES DANIEL D (US)
FAHL KATHLEEN L (US)
Application Number:
PCT/US2003/003607
Publication Date:
November 20, 2003
Filing Date:
February 07, 2003
Export Citation:
Assignee:
WISCONSIN ALUMNI RES FOUND (US)
FAHL WILLIAM E (US)
COPP RICHARD R (US)
OCHSNER CYNTHIA E (US)
PEEBLES DANIEL D (US)
FAHL KATHLEEN L (US)
FAHL WILLIAM E (US)
COPP RICHARD R (US)
OCHSNER CYNTHIA E (US)
PEEBLES DANIEL D (US)
FAHL KATHLEEN L (US)
International Classes:
A61K31/132; A61K31/133; A61K31/145; A61P17/00; A61P17/14; A61P29/00; C07C211/14; C07C211/22; C07C215/18; A61P1/00; C07C215/24; C07C323/25; C07C323/27; (IPC1-7): C07C211/14; C07C211/22; C07C323/27; C07C215/24; C07C215/18; C07C323/25; A61K31/132; A61K31/133; A61K31/145
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