Title:
POLYMYXIN B SULPHATE CRYSTAL AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2018/032506
Kind Code:
A1
Abstract:
Provided are a polymyxin B sulphate crystal and a preparation method therefor, the method comprising the following steps: using resin to perform adsorption of polymixin B fermentation broth, and adding sulphuric acid or acidic ethanol for desorption; concentrating to obtain a polymixin B sulphate saturated solution; using an organic solvent to separate out the crystals in the saturated solution, and filtering and drying to obtain the polymixin B sulphate crystal.
Inventors:
WANG ZENGXIA (CN)
LI XIAOBING (CN)
LUO FEN (CN)
LI CHANGHONG (CN)
XU YANWEI (CN)
CHEN LONG (CN)
LI XIAOBING (CN)
LUO FEN (CN)
LI CHANGHONG (CN)
XU YANWEI (CN)
CHEN LONG (CN)
Application Number:
PCT/CN2016/096063
Publication Date:
February 22, 2018
Filing Date:
August 19, 2016
Export Citation:
Assignee:
HUBEI RUIHAOANKE PHARMACEUTICAL TECH DEVELOPMENT CO LTD (CN)
International Classes:
C07K1/18; A61K38/12; A61P31/04; C07K1/36; C07K7/62
Domestic Patent References:
| WO2007142611A1 | 2007-12-13 |
Foreign References:
| CN104327167A | 2015-02-04 | |||
| US3132994A | 1964-05-12 | |||
| CN103130875A | 2013-06-05 |
Other References:
WANG, CUIYAN ET AL.: "Advances in research on 〃polymyxin B〃", RESEARCH PROGRESS OF POLYMYXIN B. CAOL AND CHEMICAL INDUSTRY, vol. 37, no. 8, 31 August 2014 (2014-08-31), pages 23 - 25 and 30, XP009515867
Attorney, Agent or Firm:
PANAWELL & PARTNERS, LLC (CN)
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