Title:
POLYNUCLEOTIDE
Document Type and Number:
WIPO Patent Application WO/2023/228968
Kind Code:
A1
Abstract:
The present invention provides a technology for enhancing the proliferation ability of CAR expressing cells. The present invention involves lowering the expression of the CUL5 gene.
Inventors:
TERAKURA SEITARO (JP)
ADACHI YOSHITAKA (JP)
KIYOI HITOSHI (JP)
ADACHI YOSHITAKA (JP)
KIYOI HITOSHI (JP)
Application Number:
PCT/JP2023/019295
Publication Date:
November 30, 2023
Filing Date:
May 24, 2023
Export Citation:
Assignee:
NATIONAL UNIV CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (JP)
International Classes:
A61K31/7088; C12N15/86; A61K31/7105; A61K31/713; A61K35/12; A61K38/16; A61K48/00; A61P35/00; C12N5/078; C12N5/10; C12N15/113; C12N15/12; C12N15/13; C12N15/62
Domestic Patent References:
| WO2021263211A2 | 2021-12-30 | |||
| WO2020014235A1 | 2020-01-16 |
Foreign References:
| CN113462723A | 2021-10-01 | |||
| JP2021184728A | 2021-12-09 |
Other References:
ADACHI, YOSHITAKA ET AL.: "PL-6: Genome-wide CRISPR-Cas9 screening to identify the genes regulating human CAR-T cells proliferation. ", PROCEEDINGS OF THE ANNUAL MEETING OF THE JAPAN SOCIETY OF HEMATOLOGY (WEB), JSH2021, JAPAN SOCIETY OF HEMATOLOGY, JP, 23 September 2021 (2021-09-23) - 25 September 2021 (2021-09-25), JP, pages 902, XP009550640
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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