Title:
POLYSUBSTITUTED ISOINDOLINE COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/083328
Kind Code:
A1
Abstract:
Disclosed are polysubstituted isoindoline compounds represented by general formula (1), a preparation method therefor, a pharmaceutical composition thereof, and the use thereof. Specifically, the disclosed polysubstituted isoindoline compounds, as a class of structurally novel CRL4CRBNE3 ubiquitin ligase modulator, have stronger anti-tumor activity and anti-tumor spectrum, and thus can be used to prepare a drug for treating diseases related to a CRL4CRBNE3 ubiquitin ligase complex.
Inventors:
CHEN XIAOHUA (CN)
LI JIA (CN)
LI SHAOTONG (CN)
ZHOU YUBO (CN)
NIE HUIJUN (CN)
WEI DAN (CN)
XU GAOYA (CN)
ZHOU BINSHAN (CN)
KAN WEIJUAN (CN)
LI JIA (CN)
LI SHAOTONG (CN)
ZHOU YUBO (CN)
NIE HUIJUN (CN)
WEI DAN (CN)
XU GAOYA (CN)
ZHOU BINSHAN (CN)
KAN WEIJUAN (CN)
Application Number:
PCT/CN2020/125270
Publication Date:
May 06, 2021
Filing Date:
October 30, 2020
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
C07D401/14; A61K31/4709; A61P35/00; C07D495/04
Domestic Patent References:
| WO2020160193A2 | 2020-08-06 |
Foreign References:
| CN110963994A | 2020-04-07 | |||
| CN110372669A | 2019-10-25 | |||
| CN109415336A | 2019-03-01 |
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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