Title:
POTENT PEPTIDE FOR STIMULATION OF CYTOTOXIC T LYMPHOCYTES SPECIFIC FOR THE HIV-1 ENVELOPE
Document Type and Number:
WIPO Patent Application WO1993018055
Kind Code:
A3
Abstract:
Peptides having high activity in the eliciting of a cytotoxic T lymphocyte response to the HIV-1 envelope glycoprotein gpl60 are described. The activation of 12-15 residue peptides by proteolytic degradation to shorter peptides is shown as are general techniques for characterizing such activation processes.
Inventors:
BERZOFSKY JAY (US)
TAKESHITA TOSHIYUKI (US)
SHIRAI MUTSUNORI (US)
PENDLETON C DAVID (US)
MARGULIES DAVID H (US)
KOZLOWSKI STEVEN (US)
TAKESHITA TOSHIYUKI (US)
SHIRAI MUTSUNORI (US)
PENDLETON C DAVID (US)
MARGULIES DAVID H (US)
KOZLOWSKI STEVEN (US)
Application Number:
PCT/US1993/001925
Publication Date:
March 17, 1994
Filing Date:
March 08, 1993
Export Citation:
Assignee:
US HEALTH (US)
International Classes:
A61K38/03; A61K38/55; A61P31/18; C07K7/06; C07K7/08; C07K14/16; C12N15/48; A61K39/00; (IPC1-7): C07K/
Domestic Patent References:
| WO1989007112A1 | 1989-08-10 | |||
| WO1991002544A1 | 1991-03-07 | |||
| WO1991014449A1 | 1991-10-03 |
Foreign References:
| EP0402088A2 | 1990-12-12 | |||
| EP0490667A2 | 1992-06-17 | |||
| EP0518672A2 | 1992-12-16 |
Other References:
KOZLOWSKI, S. ET AL.: "Serum angiotensin-1 converting enzyme activity processes a Human Immunodeficiency Virus 1 gp160 peptide for presentation by major Histocompatibility Complex Class I molecules", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 175, no. 6, June 1992 (1992-06-01), pages 1417 - 1422
US-Published-Patent-Application-7-760530 (Berzofsky, J.A.,Takahashi, H. & Germain, R.N.) (Published in NTIS GAZETTE December 15th 1992) see the whole document
TAKAHASHI, H. ET AL.: "A unique subunit immunogen iscom-gp160 can elicit MHC class-I-restricted hiv envelope-specific CD8-positive CTLs", VACCINES 91, vol. 0, no. 0, 1991, COLD SPRING HARBOR LABORATORY, pages 1 - 7
BERZOFSKY, J.A. ET AL.: "Induction of cytotoxic T cells to HIV proteins", AIDS RESEARCH AND HUMAN RETROVIRUSES, vol. 7, no. 2, February 1991 (1991-02-01), pages 144
TAKAHASHI, H. ET AL.: "An immunodominant class I-restricted cytotoxic T lymphocyte determinant of Human Immunodeficiency Virus type 1 induces CD4 class II-restricted help for itself", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 171, no. 2, 1 February 1990 (1990-02-01), pages 571 - 576
KOZLOWSKI, S. ET AL.: "A component of fetal calf serum processes a class I-restricted peptide into its active form", JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 0, no. 16D, 5 March 1992 (1992-03-05), pages 66
US-Published-Patent-Application-7-760530 (Berzofsky, J.A.,Takahashi, H. & Germain, R.N.) (Published in NTIS GAZETTE December 15th 1992) see the whole document
TAKAHASHI, H. ET AL.: "A unique subunit immunogen iscom-gp160 can elicit MHC class-I-restricted hiv envelope-specific CD8-positive CTLs", VACCINES 91, vol. 0, no. 0, 1991, COLD SPRING HARBOR LABORATORY, pages 1 - 7
BERZOFSKY, J.A. ET AL.: "Induction of cytotoxic T cells to HIV proteins", AIDS RESEARCH AND HUMAN RETROVIRUSES, vol. 7, no. 2, February 1991 (1991-02-01), pages 144
TAKAHASHI, H. ET AL.: "An immunodominant class I-restricted cytotoxic T lymphocyte determinant of Human Immunodeficiency Virus type 1 induces CD4 class II-restricted help for itself", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 171, no. 2, 1 February 1990 (1990-02-01), pages 571 - 576
KOZLOWSKI, S. ET AL.: "A component of fetal calf serum processes a class I-restricted peptide into its active form", JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 0, no. 16D, 5 March 1992 (1992-03-05), pages 66
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