Title:
PREPARATION METHOD FOR ALOE-DERIVED EXOSOME AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/108605
Kind Code:
A1
Abstract:
The present invention relates to a preparation method for an aloe-derived exosome and use thereof. Provided is a method for preparing an aloe-derived exosome, which comprises obtaining a high-purity aloe-derived exosome by combining differential centrifugation with high-speed centrifugation. The aloe-derived exosome has multiple functions, including promoting cell repair, reducing radioactive skin injury, promoting cell proliferation, promoting the epithelial-mesenchymal transition of cells, and the like. According to the present invention, the problems of low bioavailability of aloe and insufficient research on the efficacy of aloe-derived exosomes in the prior art are solved, and an effective material is provided for drugs for skin diseases. Meanwhile, the present invention provides an effective treatment means for the treatment of radioactive skin injury, which facilitates further development of treatment of cancer and other diseases.
Inventors:
KONG YI (CN)
WANG ZHE (CN)
CHEN YOU HAI (CN)
WANG XI CHENG (CN)
CHEN YU LING (CN)
WU JIA XIN (CN)
WANG ZHE (CN)
CHEN YOU HAI (CN)
WANG XI CHENG (CN)
CHEN YU LING (CN)
WU JIA XIN (CN)
Application Number:
PCT/CN2022/134520
Publication Date:
May 30, 2024
Filing Date:
November 25, 2022
Export Citation:
Assignee:
SHENZHEN INST ADV TECH (CN)
SHENZHEN INST OF ADV TECH CAS (CN)
SHENZHEN INST OF ADV TECH CAS (CN)
International Classes:
A61K36/896; A61K36/886; A61P17/00; A61P17/02; C12N5/04
Domestic Patent References:
| WO2020180311A1 | 2020-09-10 |
Foreign References:
| CN111905107A | 2020-11-10 | |||
| KR20210141261A | 2021-11-23 |
Other References:
ZENG LUPENG, WANG HUAYING, SHI WANHUA, CHEN LINGFAN, CHEN TINGTING, CHEN GUANYU, WANG WENSHEN, LAN JIANMING, HUANG ZHIHONG, ZHANG : "Aloe derived nanovesicle as a functional carrier for indocyanine green encapsulation and phototherapy", JOURNAL OF NANOBIOTECHNOLOGY, vol. 19, no. 1, 1 December 2021 (2021-12-01), pages 439, XP055922837, DOI: 10.1186/s12951-021-01195-7
MIN KANG KIM ET AL.: "The Antioxidant Effect of Small Extracellular Vesicles Derived from Aloe vera Peels for Wound Healing", JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 18, no. 4, 27 July 2021 (2021-07-27), XP037535395, DOI: 10.1007/s13770-021-00367-8
MIN KANG KIM ET AL.: "The Antioxidant Effect of Small Extracellular Vesicles Derived from Aloe vera Peels for Wound Healing", JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 18, no. 4, 27 July 2021 (2021-07-27), XP037535395, DOI: 10.1007/s13770-021-00367-8
Attorney, Agent or Firm:
SHENZHEN WULIN INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
Download PDF: