Title:
PREPARATION OF MULTI-HAPTEN MUTANT G6PDH CONJUGATES AND THEIR USE FOR DETECTION OF MULTIPLE ANALYTES
Document Type and Number:
WIPO Patent Application WO/2015/094852
Kind Code:
A3
Abstract:
The present invention relates to multi-hapten mutant G6PDH conjugates, methods of their preparation and their use for detection of multiple analytes. The compositions of the invention comprise different types of haptens (molecules) require to be immobilized into the G6PDH to make one multi-hapten-G6PDH conjugate.Both thiol and amine functional groups on G6PDH are utilized for immobilization of different haptens.
Inventors:
ZHENG YI FENG (US)
YANG YALI (US)
HUDSON LINDA (US)
MORJANA NIHMAT (US)
YANG YALI (US)
HUDSON LINDA (US)
MORJANA NIHMAT (US)
Application Number:
PCT/US2014/069532
Publication Date:
August 13, 2015
Filing Date:
December 10, 2014
Export Citation:
Assignee:
SIEMENS HEALTHCARE DIAGNOSTICS (US)
International Classes:
C12N9/04; C07K1/00; C12Q1/32; G01N33/53; G01N33/536; G01N33/566
Foreign References:
| US20030224373A1 | 2003-12-04 | |||
| US6455288B1 | 2002-09-24 | |||
| US20070218506A1 | 2007-09-20 |
Other References:
OLIVE ET AL.: "Glucose 6-phosphate dehydrogenase from Leuconostoc mesenteroides. Kinetic studies.", J BIOL CHEM., vol. 246, no. 7, 1971, pages 2047 - 57, XP055219743
"G-Biosciences, Double-Do Protein Cross-Linkers", HANDBOOK & SELECTION GUIDE, G- BIOSCIENCES, 2010, XP055180499, Retrieved from the Internet [retrieved on 20150317]
"G-Biosciences, Double-Do Protein Cross-Linkers", HANDBOOK & SELECTION GUIDE, G- BIOSCIENCES, 2010, XP055180499, Retrieved from the Internet
Attorney, Agent or Firm:
TYMESON, Cynthia et al. (Intellectual Property Dept.3501 Quadrangle Blvd Ste 23, Orlando Florida, US)
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