Title:
PREVENTION OF DEFICITS IN NEUROGENESIS WITH ANTI-INFLAMMATORY AGENTS
Document Type and Number:
WIPO Patent Application WO2004093802
Kind Code:
A3
Abstract:
Methods are provided for protecting an individual from adverse long-term effects of neuroinflammation. Inflammatory blockade maintains neurogenesis capability after cranial irradiation by reducing the negative effects of activated microglia on neural precursor cells. These findings have broad implications for a variety of diseases of cognition, involving neuroinflammation and precursor cell dysfunction.
Inventors:
MONJE MICHELLE L (US)
PALMER THEO D (US)
PALMER THEO D (US)
Application Number:
PCT/US2004/011936
Publication Date:
September 21, 2006
Filing Date:
April 16, 2004
Export Citation:
Assignee:
UNIV LELAND STANFORD JUNIOR (US)
MONJE MICHELLE L (US)
PALMER THEO D (US)
MONJE MICHELLE L (US)
PALMER THEO D (US)
International Classes:
A01N43/56; A61K31/00; A61K31/415; A61K31/60; A61N5/00; A61K
Other References:
SASAKI ET AL.: "Inplication of cyclooxygenase-2 on enhanced proliferation of neural progenitor cells in the adult mouse hippocampus after ischemia", J. NEURSCI. RES., vol. 72, no. 4, May 2003 (2003-05-01), pages 461 - 471, XP003003659
MONJE ET AL.: "Inflammatory blockade restores adult hippocampal neurogenesis", SCIENCE, vol. 302, no. 5651, December 2003 (2003-12-01), pages 1760 - 1765, XP003003658
HOEHN ET AL.: "Neurogenesis in rats after focal cerebral ischemia is enhance by Indomethacin", STROKE, vol. 36, no. 12, December 2005 (2005-12-01), pages 2718 - 2724, XP003003657
MONJE ET AL.: "Inflammatory blockade restores adult hippocampal neurogenesis", SCIENCE, vol. 302, no. 5651, December 2003 (2003-12-01), pages 1760 - 1765, XP003003658
HOEHN ET AL.: "Neurogenesis in rats after focal cerebral ischemia is enhance by Indomethacin", STROKE, vol. 36, no. 12, December 2005 (2005-12-01), pages 2718 - 2724, XP003003657
Download PDF:
Previous Patent: PHARMACEUTICAL PRODUCTS
Next Patent: PHOTOCHEMOTHERAPEUTIC COMPOUNDS FOR USE IN TREATMENT OF PIN1-ASSOCIATED STATES
Next Patent: PHOTOCHEMOTHERAPEUTIC COMPOUNDS FOR USE IN TREATMENT OF PIN1-ASSOCIATED STATES