Title:
PROBUCOL MONOESTERS AND THEIR USE TO INCREASE PLASMA HDL CHOLESTEROL LEVELS AND IMPROVE HDL FUNCTIONALITY
Document Type and Number:
WIPO Patent Application WO2002087556
Kind Code:
A9
Abstract:
It has been discovered that certain selected probucol monoesters, and their pharmaceutically acceptable salts or prodrugs, are useful for increasing circulating HDL cholesterol. These compounds may also improve HDL functionality by (a) increasing clearance of cholesteryl esters, (b) increasing HDL-particle affinity for hepatic cell surface receptors or (c) increasing the half life of apoAI-HDL.
Inventors:
LUCHOOMUN JAYRAZ (US)
SAXENA UDAY (US)
SUNDELL CYNTHIA L (US)
SIKORSKI JAMES A (US)
SAXENA UDAY (US)
SUNDELL CYNTHIA L (US)
SIKORSKI JAMES A (US)
Application Number:
PCT/US2002/012678
Publication Date:
March 20, 2003
Filing Date:
April 11, 2002
Export Citation:
Assignee:
ATHEROGENICS INC (US)
LUCHOOMUN JAYRAZ (US)
SAXENA UDAY (US)
SUNDELL CYNTHIA L (US)
SIKORSKI JAMES A (US)
LUCHOOMUN JAYRAZ (US)
SAXENA UDAY (US)
SUNDELL CYNTHIA L (US)
SIKORSKI JAMES A (US)
International Classes:
A61K31/05; A61K31/10; A61K31/138; A61K45/00; A61K31/198; A61K31/216; A61K31/22; A61K31/225; A61K31/235; A61K31/255; A61K31/275; A61K31/40; A61K31/4184; A61K31/4422; A61K31/4706; A61K31/472; A61K31/502; A61K31/506; A61K31/517; A61K31/55; A61K31/554; A61K31/575; A61K45/06; A61P3/06; A61P9/10; C07C323/20; C07C323/21; (IPC1-7): A61K31/225; A61K31/255; A61P9/10
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