Title:
PROCESS FOR THE ENANTIOSELECTIVE SYNTHESIS OF A TETRAHYDROBENZAZEPINE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2014/060575
Kind Code:
A3
Abstract:
This invention relates to an improved process for the enantioselective synthesis of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
Inventors:
DURAN LÓPEZ ERNESTO (ES)
Application Number:
PCT/EP2013/071832
Publication Date:
August 14, 2014
Filing Date:
October 18, 2013
Export Citation:
Assignee:
MEDICHEM SA (ES)
International Classes:
C07D223/16
Domestic Patent References:
| WO2007149728A2 | 2007-12-27 | |||
| WO2009105206A1 | 2009-08-27 | |||
| WO2005003096A1 | 2005-01-13 | |||
| WO2008080891A2 | 2008-07-10 |
Foreign References:
| US6953787B2 | 2005-10-11 | |||
| US20080045502A1 | 2008-02-21 |
Other References:
SMITH BRIAN M ET AL: "Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 51, no. 2, 1 January 2008 (2008-01-01), pages 305 - 313, XP009138515, ISSN: 0022-2623, [retrieved on 20071221], DOI: 10.1021/JM0709034
SMITH B M ET AL: "Discovery and SAR of new benzazepines as potent and selective 5-HT2C receptor agonists for the treatment of obesity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, GB, vol. 15, no. 5, 1 March 2005 (2005-03-01), pages 1467 - 1470, XP027801904, ISSN: 0960-894X, [retrieved on 20050301]
SMITH B M ET AL: "Discovery and SAR of new benzazepines as potent and selective 5-HT2C receptor agonists for the treatment of obesity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, GB, vol. 15, no. 5, 1 March 2005 (2005-03-01), pages 1467 - 1470, XP027801904, ISSN: 0960-894X, [retrieved on 20050301]
Attorney, Agent or Firm:
CARBONELL VALLÉS, Enric (S.LEdificio Euromor,Avenida de Burgos 16, Edificio Euromor Madrid, ES)
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