Title:
PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE TRANS-CYCLOHEXYLAMINE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2000/000459
Kind Code:
A1
Abstract:
A process for the preparation of optically active cyclohexylamine compounds useful as intermediates for the preparation of 1-phenyl-2-(3-phenylcyclohexyl-amino)ethanol compounds exhibiting a selective $g(b)¿3?-adreneric receptor stimulating effect; N-substituted-3-phenylcyclohexylamine compounds as intermediates for the preparation; and 3-phenyl-2-cyclohexen-1-one compounds as raw materials therefor. The above process comprises conducting the reductive amination of a 3-phenyl-2-cyclohexen-1-one compound with an optically active amine compound through a Schiff base forming reaction and freeing the obtained product from the substituent on the nitrogen atom.
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Inventors:
KAJITA TSUYOSHI (JP)
MATSUMOTO TOSHIFUMI (JP)
MATSUMOTO TOSHIFUMI (JP)
Application Number:
PCT/JP1999/003444
Publication Date:
January 06, 2000
Filing Date:
June 28, 1999
Export Citation:
Assignee:
MITSUBISHI TOKYO PHARM INC (JP)
KAJITA TSUYOSHI (JP)
MATSUMOTO TOSHIFUMI (JP)
KAJITA TSUYOSHI (JP)
MATSUMOTO TOSHIFUMI (JP)
International Classes:
C07C209/26; C07C213/02; C07C211/40; C07C215/64; C07C217/74; (IPC1-7): C07C213/02; B01J25/02; C07B53/00; C07C49/747; C07C49/753; C07C69/738; C07C215/64; C07C217/74
Foreign References:
| JPH04234832A | 1992-08-24 | |||
| JPS5032169A | 1975-03-28 | |||
| DE3827675A1 | 1989-03-02 | |||
| JPH0959631A | 1997-03-04 |
Attorney, Agent or Firm:
Matsuyama, Naoyuki (Inc. 2-6, Nihonbashi-honcho 2-chome Chuo-ku Tokyo, JP)
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