PROCESS FOR PREPARING ASYMMETRIC COMPOUND BY USING METAL COMPLEX

WIPO Patent Application WO/1996/029295

A1

A process for preparing an asymmetric compound by using a metal complex which enables the preparation of an optically active substance not containing any rare earth metal element and having a high optical purity. A metal complex composed of an optically active binaphthol of general formula (1), aluminum and an alkali metal (or an alkaline earth metal) is prepared by reacting the optically active binaphthol with lithium aluminum hydride or with a dialkylaluminum hydride and a base containing an alkali metal (or an lakaline earth metal). The use of this metal complex in the asymmetric Michael reaction or asymmetric phosphonylation as the catalyst makes it possible to prepare an asymmetric compound having a high optical purity in a high yield.

SHIBASAKI MASAKATSU (JP)
SASAI HIROAKI (JP)
ARAI TAKAYOSHI (JP)

PCT/JP1996/000739

September 26, 1996

March 21, 1996

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NAGASE & CO LTD (JP)
SHIBASAKI MASAKATSU (JP)
SASAI HIROAKI (JP)
ARAI TAKAYOSHI (JP)

B01J31/02; B01J31/14; C07B53/00; C07B61/00; C07C67/333; C07C67/347; C07C69/716; B01J31/22; C07C69/738; C07F9/40; (IPC1-7): C07B37/02; C07B53/00; C07C67/347; C07C69/716; C07F9/40; B01J31/22

JPH07265709A	1995-10-17
JPH0240344A	1990-02-09

JOURNAL OF SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, Tokyo, Japan, Vol. 51, No. 11, November 1993, MASAKATSU SHIBAZAKI, HIROAKI SASAI, "Catalytic Asymmetric Carbon Using Optically Active Rare Earch Complex-Carbon Couple Producing Reaction", pages 972-984.

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