Title:
PROCESS FOR PRODUCING ENANTIOMER OF AMLODIPINE IN HIGH OPTICAL PURITY
Document Type and Number:
WIPO Patent Application WO2006043148
Kind Code:
B1
Abstract:
The present invention relates to a process for preparation of optically pure (S)-amlodipine-L-hemitartrate DMF solvate comprising the steps of treating (R,S) amlodipine base with L-tartaric acid in the presence of dimethyl formamide and a co-solvent. The invention also relates to a process for converting (R) or(S)-amlopidine-L-hemitartrate DMF solvate into their besylates without isolating free chiral amlopidine base after solution.
Inventors:
GHARPURE MILIND MORESHWAR (IN)
BHAWAL BABURAO MANIKRAO (IN)
RANADE PRASAD VASUDEO (IN)
DESHMUKH RAJENDRA DAGADU (IN)
MEHTA SATISH RAMANLAL (IN)
BHAWAL BABURAO MANIKRAO (IN)
RANADE PRASAD VASUDEO (IN)
DESHMUKH RAJENDRA DAGADU (IN)
MEHTA SATISH RAMANLAL (IN)
Application Number:
PCT/IB2005/003108
Publication Date:
June 08, 2006
Filing Date:
October 17, 2005
Export Citation:
Assignee:
EMCURE PHARMACEUTICALS LTD (IN)
GHARPURE MILIND MORESHWAR (IN)
BHAWAL BABURAO MANIKRAO (IN)
RANADE PRASAD VASUDEO (IN)
DESHMUKH RAJENDRA DAGADU (IN)
MEHTA SATISH RAMANLAL (IN)
GHARPURE MILIND MORESHWAR (IN)
BHAWAL BABURAO MANIKRAO (IN)
RANADE PRASAD VASUDEO (IN)
DESHMUKH RAJENDRA DAGADU (IN)
MEHTA SATISH RAMANLAL (IN)
International Classes:
C07D211/90
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