Title:
PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE β-HYDROXY-&agr -AMINOCARBOXYLIC ACID DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2005/005371
Kind Code:
A1
Abstract:
[PROBLEMS] To provide a process for efficient production of optically active β-hydroxy-&agr -aminocarboxylic acid derivatives of anti conformation useful as intermediates of drugs or agricultural chemicals. [MEANS FOR SOLVING PROBLEMS] A process for the production of optically active β-hydroxy-&agr -aminocarboxylic acid derivatives represented by the general formula (2) or (3): [wherein R1 is substituted or unsubstituted C1-20 alkyl or a substituted or unsubstituted C4-12 aromatic group; and R2 is substituted or unsubstituted C1-20 alkyl or a substituted or unsubstituted C4-12 aromatic group], characterized by hydrogenating an &agr -aminoacylacetate ester represented by the general formula (1): [wherein R1 and R2 are each as defined above] through catalytic asymmetric hydrogenation in the presence of an acid.
Inventors:
HAMADA YASUMASA (JP)
MAKINO KAZUISHI (JP)
MAKINO KAZUISHI (JP)
Application Number:
PCT/JP2004/009829
Publication Date:
January 20, 2005
Filing Date:
July 09, 2004
Export Citation:
Assignee:
NISSAN CHEMICAL IND LTD (JP)
HAMADA YASUMASA (JP)
MAKINO KAZUISHI (JP)
HAMADA YASUMASA (JP)
MAKINO KAZUISHI (JP)
International Classes:
C07C227/32; C07C229/22; (IPC1-7): C07C227/32; C07C229/22; C07C229/28; C07B53/00; B01J31/24
Foreign References:
| JPH02172956A | 1990-07-04 | |||
| JPH0680617A | 1994-03-22 | |||
| JPS63310847A | 1988-12-19 | |||
| JPH0680617A | 1994-03-22 | |||
| JPH02172956A | 1990-07-04 |
Other References:
J. AM. CHEM.SOC., vol. 111, 1989, pages 9134 - 9135
SYNTHESIS, 1992, pages 1248 - 1254
SYNTHESIS, 1992, pages 1248 - 1254
Attorney, Agent or Firm:
Hanabusa, Tsuneo c/o Hanabusa, Patent Office (Shin-Ochanomizu Urban Trinity 2,
Kandasurugadai 3-chom, Chiyoda-ku Tokyo, JP)
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