Title:
PROCESS FOR SYNTHESIZING 4-SUBSTITUTED AZETIDINONE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/1994/018163
Kind Code:
A1
Abstract:
The invention relates to a process for synthesizing a 4-substituted azetidinone derivative represented by the general formula (3) (wherein OR1 represents a protected hydroxyl group; CO2R3 represents an esterified carboxyl group; and X and Y represent each independently alkyl, alkenyl, aralkyl, aryl, alkylthio, alkoxy, heterocycle, acyl, amino, hydrogen or halogen, or alternatively X and Y are combined together to represent cycloalkan-2-on-2-yl) by the reaction of an azetidinone derivative represented by general formula (1) (wherein OR1 is as defined above; and R2 represents alkyl, alkenyl or aryl) with an ester compound represented by general formula (2): (wherein CO2R3, X and Y are each as defined above) in the presence of zinc and copper compounds. The invention relates also to a compound represented by general formula (3) and further to a compound prepared by decarboxylating the compound (3), both being useful as an intermediate for synthesizing antibacterial carbapenem compounds.
Inventors:
ISHIGURO MASAJI (JP)
NAKATSUKA TAKASHI (JP)
TANAKA RIE (JP)
SHIMAMOTO TETSUO (JP)
YOSHIDA TAKURO (JP)
NAKATSUKA TAKASHI (JP)
TANAKA RIE (JP)
SHIMAMOTO TETSUO (JP)
YOSHIDA TAKURO (JP)
Application Number:
PCT/JP1994/000195
Publication Date:
August 18, 1994
Filing Date:
February 10, 1994
Export Citation:
Assignee:
SUNTORY LTD (JP)
ISHIGURO MASAJI (JP)
NAKATSUKA TAKASHI (JP)
TANAKA RIE (JP)
SHIMAMOTO TETSUO (JP)
YOSHIDA TAKURO (JP)
ISHIGURO MASAJI (JP)
NAKATSUKA TAKASHI (JP)
TANAKA RIE (JP)
SHIMAMOTO TETSUO (JP)
YOSHIDA TAKURO (JP)
International Classes:
C07D205/08; (IPC1-7): C07D205/08
Foreign References:
JPS56150058A | 1981-11-20 | |||
JPS56154458A | 1981-11-30 | |||
JPS5946265A | 1984-03-15 | |||
JPS61165365A | 1986-07-26 | |||
JPS62246550A | 1987-10-27 |
Other References:
See also references of EP 0638552A4
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