Title:
PROCESS TO OBTAIN DIBENZYLBUTYROLACTONIC, TETRAHYDROFURANIC LIGNANS AND THEIR SYNTHETIC AND SEMI-SYNTHETIC DERIVATIVES, THEIR ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES, TOPICAL AND/OR SYSTEMIC FORMULATIONS CONTAINING SAID LIGNANS AND THEIR RESPECTIV
Document Type and Number:
WIPO Patent Application WO2006113981
Kind Code:
A3
Abstract:
The present invention refers to a process to obtain dibenzylbutyrolactonic lignans form (-)- cubebin, insolate from a Piperaceae, especially Piper cubeba, and from (-)-methylpluviatolide insolated form a Rutacea, especially Zanthoxylum naranjillo; their synthetic and semisyntheti derivatives and tetrahydrofuranic lignans, such as glagravin and veragensin, insolated form Nectandra meapotamica, as well as the analgesic and anti-inflammatory activities of said lignans, and the topical and/or systemic formulatins where lignans present 60 to 80% of the formulation. The invention also refers to a therapeutic method using topic and/or systemic formulations based on said lignans for the treatment of inflammation and/or pain. More specifically, it refers to a process to obtain synthetic and semi-synthetic derivatives of (-)- cubebin such as: - -O-acet l cubebin; - -O-meth l cubebin - -O- N N-dimeth lamino-ethyl)- cubebin; (-)-hinokinin; (-)6,6'-dinitroinokinin; (-)-o-benzyl cubebin; (-)-6,6'-diaminohinokinin and other synthetic derivatives which may be obtained, and synthetic and semi-synthetic derivatives of (-)-methylpluviatolide, such as (-)-6,6'-dinitromethylpluviatolide and (-)6,6'- diaminomethylpluviatolide, to be used in the manufacture of medicine that has analgesic and anti-inflammatory activity. The present invention also refers to the process ot obtain the substances glagravin and veragensin islated from Nectandra megapotamica, as well as their synthetic and semi-synthetic derivatives with substituents on the aromatic rings that may be obtained.
Inventors:
SILVA MARCIO LUIS ANDRADE E (BR)
BASTOS JAIRO KENUPP (BR)
DONATE PAULO MARCOS (BR)
ALBUQUERQUE SERGIO DE (BR)
SILVA ROSANGELA DA (BR)
BASTOS JAIRO KENUPP (BR)
DONATE PAULO MARCOS (BR)
ALBUQUERQUE SERGIO DE (BR)
SILVA ROSANGELA DA (BR)
Application Number:
PCT/BR2006/000084
Publication Date:
December 14, 2006
Filing Date:
April 28, 2006
Export Citation:
Assignee:
FUNDACAO DE AMPARO A PESQUISA (BR)
SILVA MARCIO LUIS ANDRADE E (BR)
BASTOS JAIRO KENUPP (BR)
DONATE PAULO MARCOS (BR)
ALBUQUERQUE SERGIO DE (BR)
SILVA ROSANGELA DA (BR)
SILVA MARCIO LUIS ANDRADE E (BR)
BASTOS JAIRO KENUPP (BR)
DONATE PAULO MARCOS (BR)
ALBUQUERQUE SERGIO DE (BR)
SILVA ROSANGELA DA (BR)
International Classes:
C07D407/10; C07D407/12; A61K31/36; A61P29/00; C07D407/14
Domestic Patent References:
| WO2003080600A1 | 2003-10-02 |
Other References:
DA SILVA FILHO A.A. ET AL.: "Tetrahydrofuran lignans from Nectandra megapotamica with trypanocidal activity", JOURNAL OF NATURAL PRODUCTS, vol. 67, no. 1, 2004, pages 42 - 45, XP003004499
See also references of EP 1917260A4
See also references of EP 1917260A4
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