Title:
PROCESSES FOR PREPARATION OF HETEROCYCLIC COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2002/100850
Kind Code:
A1
Abstract:
A process for preparation of heterocyclic compounds represented by the general formula (I), characterized by cyclizing an acetal (II) or an aldehyde (III) in the presence of a phosphoric acid compound in a molar amount below that of the acetal or the aldehyde&semi and a process for preparation of 1−substituted indoles represented by the general formula (VII), characterized by cyclizing an N−substituted anilinoacet− aldehyde acetal (VI) in the presence of an acid. (II) (III) (I) (VI) (VII) (In the formulae, R1, R2, R3, R4, R8, R9, R10, and X are each as defined in the description.)
More Like This:
Inventors:
MATSUDA HIDEKI (JP)
TORIHARA MASAHIRO (JP)
TAMAI YOSHIN (JP)
TORIHARA MASAHIRO (JP)
TAMAI YOSHIN (JP)
Application Number:
PCT/JP2002/005594
Publication Date:
December 19, 2002
Filing Date:
June 06, 2002
Export Citation:
Assignee:
KURARAY CO (JP)
MATSUDA HIDEKI (JP)
TORIHARA MASAHIRO (JP)
TAMAI YOSHIN (JP)
MATSUDA HIDEKI (JP)
TORIHARA MASAHIRO (JP)
TAMAI YOSHIN (JP)
International Classes:
C07C319/14; C07D209/04; C07C323/22; (IPC1-7): C07D307/79; C07C323/22; C07C323/62; C07D209/08; C07D333/54
Domestic Patent References:
| WO2001021606A1 | 2001-03-29 |
Foreign References:
| JPH11508888A | 1999-08-03 | |||
| JP2000511518A | 2000-09-05 | |||
| JP2000505815A | 2000-05-16 | |||
| GB2193211A | 1988-02-03 | |||
| JPH08506348A | 1996-07-09 |
Other References:
PLE PATRIC A., MARNETT LAWRENCE J.: "Synthesis of substituted benzo(b)thiofenes by acid-catalyzed cyclization of thiofenyl acetals and ketones", J. HETEROCYCLIC CHEM., vol. 25, 1988, pages 1271 - 1272, XP002956647
LARSEN JAN, BECHGAARD KLAUS: "Thiaheterohelicenes. 2. Synthesis of alkylated thiaheterohelicenes", ACTA CHEM. SCAND., vol. 50, no. 1, 1996, pages 77 - 82, XP002956648
SUNDBERG RICHARD J., LAURINO JOSEPH P.: "Cyclization of 2-(N-(methylsulfonyl)anilino)acetaldehyde diethyl acetals to indoles. Evidence for stereoelectronic effects in intramolecular electrophilic aromatic substitution", J. ORG. CHEM., vol. 49, no. 2, 1984, pages 249 - 254, XP002956649
LARSEN JAN, BECHGAARD KLAUS: "Thiaheterohelicenes. 2. Synthesis of alkylated thiaheterohelicenes", ACTA CHEM. SCAND., vol. 50, no. 1, 1996, pages 77 - 82, XP002956648
SUNDBERG RICHARD J., LAURINO JOSEPH P.: "Cyclization of 2-(N-(methylsulfonyl)anilino)acetaldehyde diethyl acetals to indoles. Evidence for stereoelectronic effects in intramolecular electrophilic aromatic substitution", J. ORG. CHEM., vol. 49, no. 2, 1984, pages 249 - 254, XP002956649
Download PDF: