Title:
PROCESSES FOR PRODUCING OPTICALLY ACTIVE N-(2,3-EPOXYPROPAN-1-YL)PHTHALIMIDE
Document Type and Number:
WIPO Patent Application WO/2004/037815
Kind Code:
A1
Abstract:
Processes by which an optically active N-(2,3-epoxypropan-1-yl)phthalimide useful as an intermediate for medicines can be easily produced from an easily available starting material. An easily available, optically active (2,3-epoxypropan-1-yl)arylsulfonate is reacted with a phthalimidate to thereby produce an optically active N-(2,3-epoxypropan-1-yl)phthalimide. Alternatively, an easily available, optically active (2,3-epoxypropan-1-yl)arylsulfonate is reacted with phthalimide and a base to thereby produce an optically active N-(2,3-epoxypropan-1-yl)phthalimide.
Inventors:
NISHIYAMA AKIRA (JP)
KISHIMOTO NARUMI (JP)
NAGASHIMA NOBUO (JP)
KISHIMOTO NARUMI (JP)
NAGASHIMA NOBUO (JP)
Application Number:
PCT/JP2003/013014
Publication Date:
May 06, 2004
Filing Date:
October 09, 2003
Export Citation:
Assignee:
KANEKA CORP (JP)
NISHIYAMA AKIRA (JP)
KISHIMOTO NARUMI (JP)
NAGASHIMA NOBUO (JP)
NISHIYAMA AKIRA (JP)
KISHIMOTO NARUMI (JP)
NAGASHIMA NOBUO (JP)
International Classes:
C07D405/06; (IPC1-7): C07D405/06
Domestic Patent References:
| WO2001085679A1 | 2001-11-15 |
Foreign References:
| JPS6042375A | 1985-03-06 | |||
| JP2002179634A | 2002-06-26 | |||
| JPH09301947A | 1997-11-25 |
Other References:
ZAKERINIA M. ET AL: "The synthesis of purine and pyrimidine secoribonucleosides.", HELVETICA CHIMICA ACTA, vol. 73, no. 4, 1990, pages 912 - 915, XP002986224
ELWOOD T. ET AL: "Identification by distribution studies of 4-aminoquinoline antimalarials.", JOURNAL OF ORGANIC CHEMISTRY, vol. 13, 1948, pages 39 - 62, XP002986225
"Shin Jikken Kagaku Koza 14 Yuki Kagobutsu no Gosei to Hanno", EDITED BY CSJ: THE CHEMICAL SOCIETY OF JAPAN, 1977, pages 132 - 135, XP002986226
ELWOOD T. ET AL: "Identification by distribution studies of 4-aminoquinoline antimalarials.", JOURNAL OF ORGANIC CHEMISTRY, vol. 13, 1948, pages 39 - 62, XP002986225
"Shin Jikken Kagaku Koza 14 Yuki Kagobutsu no Gosei to Hanno", EDITED BY CSJ: THE CHEMICAL SOCIETY OF JAPAN, 1977, pages 132 - 135, XP002986226
Attorney, Agent or Firm:
KANEKA CORPORATION (Kita-ku Osaka-shi, Osaka, JP)
Download PDF:
Previous Patent: PYRROLIDIN-2-ON DERIVATIVES AS EP4 RECEPTOR AGONISTS
Next Patent: BENZOFURAN COMPOUNDS HAVING ANTITUMOR ACTIVITY
Next Patent: BENZOFURAN COMPOUNDS HAVING ANTITUMOR ACTIVITY