Title:
PRODUCTION OF A CONCENTRATED SOLUTION CONSISTING OF BIOLOGICAL SUBSTANCES
Document Type and Number:
WIPO Patent Application WO2006005305
Kind Code:
A3
Abstract:
The invention relates to a method for producing a concentrated solution consisting of biological substances such as, e.g. viruses, virus particles, antibodies and proteins, while using a bioreactor system having a filtering unit provided in the form of a membrane or of a membrane system. The yield and the level of the concentration of the unstable biological products are positively influenced by integrating a parameter control unit for depicting different levels of one or more process parameters during the production process. The bioreactor and filtering unit are connected to form a bioreactor system in which, during filtration, the unstable biological substances are cooled and retained in the membrane system, and the filtrate is optionally returned to the bioreactor.
Inventors:
CZERMAK PETER (DE)
NEHRING DIRK (DE)
NEHRING DIRK (DE)
Application Number:
PCT/DE2005/001173
Publication Date:
May 11, 2006
Filing Date:
July 04, 2005
Export Citation:
Assignee:
FACHHOCHSCHULE GIESSEN FRIEDBE (DE)
CZERMAK PETER (DE)
NEHRING DIRK (DE)
CZERMAK PETER (DE)
NEHRING DIRK (DE)
International Classes:
C12M3/00; C12M1/04
Domestic Patent References:
| WO2003064586A2 | 2003-08-07 | |||
| WO2003070873A2 | 2003-08-28 |
Foreign References:
| US20010034055A1 | 2001-10-25 | |||
| US6139746A | 2000-10-31 | |||
| EP1371723A1 | 2003-12-17 |
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